3D打印壳聚糖水凝胶的设计制备及其在生物医学中的应用

Design and Preparation of 3D Printed Chitosan Hydrogels and Its Application in Biomedicine

壳聚糖水凝胶具有良好的生物相容性和生物降解性能,被广泛的应用于生物医学领域。壳聚糖水凝胶通常是壳聚糖溶液通过凝胶化过程形成交联结构。具有复杂结构的壳聚糖水凝胶不能通过传统方式制备,进而限制了它在生物医学中的应用。3D打印技术是一种先进的制造技术,可以通过设计模型和调整打印参数制备具有个性化的水凝胶支架和具有高度复杂几何结构的水凝胶,这种水凝胶可以负载细胞和药物,以加速组织再生。壳聚糖水凝胶与3D打印结合在生物医学领域具有广阔的前景。综述了3D打印壳聚糖水凝胶的最新研究进展,根据交联策略的不同,从物理交联壳聚糖水凝胶和化学交联壳聚糖水凝胶两个方向分析了壳聚糖水凝胶的形成机理,讨论了常用的3D打印技术原理,包括喷墨式3D打印、挤出式3D打印以及光固化3D打印(立体光固化成型和投影式光固化成型),介绍了3D打印壳聚糖水凝胶在皮肤伤口愈合、骨组织工程、神经组织工程和药物递送系统中的应用,并对3D打印壳聚糖水凝胶在生物医学中的应用进行展望。

Chitosan hydrogels have been widely used in biomedical applications because of their good biocompatibility and biodegradability properties.Chitosan hydrogels are usually prepared from chitosan solutions,which form a solid structure through a gelation process.Chitosan hydrogels with complex structure cannot be prepared by traditional methods,which limits its application in biomedicine field.3D printing is an advanced manufacturing technology that allows for the preparation of hydrogels with personalized scaffolds and highly complex geometries by adjusting the printing parameters.These hydrogels can be loaded with cells and drugs to accelerate tissue regeneration.These hydrogels can be loaded with cells and drugs to accelerate tissue regeneration.The combination of chitosan hydrogels and 3D printing has a broad prospect in the biomedical field.This paper reviewed recent research progress on 3D printed chitosan hydrogels,discussed different crosslinking strategies such as physical and chemical crosslinking,explored common 3D printing technologies including inkjet,extrusion,and light-curing,and examines applications of 3D printed chitosan hydrogels in skin wound healing,bone tissue engineering,neural tissue engineering,and drug delivery systems.Future prospects for the use of 3D printed chitosan hydrogels in biomedicine were also outlined.