糖萼参与肾脏纤维化的机制

Mechanism of glycocalyx involved in renal interstitial fibrosis

肾脏纤维化是慢性肾脏病(CKD)进展至终末期肾病的共同病理特征,明确肾脏纤维化发生的分子机制对CKD的防治至关重要。内皮细胞表层的多糖蛋白复合物——糖萼组成了血液和血管壁之间最基本的屏障。最新研究显示,糖萼在肾脏纤维化过程中发挥重要作用。本文就糖萼参与肾脏纤维化发生的相关研究进展作一综述,为其防治提供新的治疗策略。

Renal fibrosis is a common outcome of various causes leading to the development of chronic kidney disease(CKD)to end-stage renal disease.It's crucial for the treatment of CKD patients to clarify the molecular mechanisms of renal fibrosis.There is a layer of polysaccharide protein complex(also called glycocalyx)on the endothelial cell surface,which constitutes the basic barrier between the blood and the vessel wall.Recent studies have shown that the glycocalyx degradation plays an important role in promoting renal fibrosis.This review will discuss the research progress on the mechanisms of glycocalyx involved in renal interstitial fibrosis and may provide new therapeutic strategies for CKD.