期刊文献+

子痫前期患者血清铁调素水平变化与妊娠结局的关系分析

下载PDF
导出
摘要 目的探究子痫前期患者血清铁调素水平变化与妊娠结局的关系。方法选取2019年10月至2022年10月河北省唐山市妇幼保健院收治的159例子痫前期患者作为病例组,另选取河北省唐山市妇幼保健院同期159例健康孕妇作为对照组。将子痫前期患者进一步分为不良妊娠组、妊娠良好组。比较病例组和对照组、不良妊娠组和妊娠良好组血清铁调素水平,分析子痫前期患者血清铁调素水平与妊娠结局的关系。结果对照组血清铁调素水平低于病例组(P<0.05)。随访至分娩,159例子痫前期患者中共40例发生不良妊娠结局,占25.16%。不良妊娠组血清铁调素、铁蛋白、血红蛋白(Hb)、平均血红蛋白浓度(MCHC)均高于妊娠良好组,可溶性转铁蛋白受体(sTfR)、转铁蛋白(TRF)低于妊娠良好组(P<0.05)。多因素logistic回归分析结果显示,铁调素水平高、铁蛋白水平高、sTfR水平低、TRF水平低、Hb水平高、MCHC水平高是子痫前期患者发生不良妊娠结局的影响因素(P<0.05)。绘制受试者工作特征曲线,结果显示,血清铁调素对子痫前期患者妊娠结局有一定的预测价值,曲线下面积为0.811。子痫前期患者血清铁调素与铁蛋白、Hb、MCHC呈正相关(r>0,P<0.05),与sTfR、TRE呈负相关(P<0.05)。结论子痫前期患者血清铁调素水平变化与妊娠结局密切相关。
出处 《中国临床医生杂志》 2024年第7期850-853,共4页 Chinese Journal For Clinicians
基金 2022年河北省医学科学研究课题计划项目(20221770)。
  • 相关文献

参考文献12

二级参考文献100

  • 1American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy.Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy [J]. Obstet Gynecol, 2013, 122(5):1122-1131.
  • 2Magee LA, Pels A, Helewa M, et al.Canadian Hypertensive Disorders of Pregnancy Working Group. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy: executive summary[J]. J Obstet Gynaecol Can, 2014, 36(5):416-441.
  • 3Visintin C, Mugglestone MA, Almerie MQ, et al. Management of hypertensive disorders during pregnancy: summary of NICE guidance[J]. BMJ, 2010, 341 :c2207.
  • 4Lowe SA, Bowyer L, Lust K, et al. The SOMANZ Guidelines for the Management of Hypertensive Disorders of Pregnancy 2014[J]. Aust N Z J Obstet Gynaecol, 2015, 55(1):11-16.
  • 5Campos-Outcah D Sr. US Preventive Services Task Force: the gold standard of evidence-based prevention[J]. J Fam Pract, 2005, 54(6):517-519.
  • 6Magee LA, Hdewa M, Momquin JM, et al. Diagnosis, evaluation,and management of the hypertensive disorders of pregnancy[J]. J Obstet Gynaeeol Can, 2008, 30 (Suppl): S1-48.
  • 7Cote AM, Brown MA, Laln E, et al. Diagnostic accuracy of urinary spot protein: creatiniue ratio for proteinuria in hypertensive pregnant women: systematic review[J]. BMJ, 2008, 336(7651): 1003-1006.
  • 8Churchill D, Beevers GD, Meher S, et al, Diuretics for preventing pre-eclampsia[J]. Cochrane Database Syst Rev, 2007, 24 (1):CD004451.
  • 9McCoy S, Baldwin K. Pharmacotherapeutie options for the treatment of preeelampsia[J]. Am J Health Syst Pharm, 2009, 66(4):337-344.
  • 10Duley L, Gfilmezoglu AM, Chou D. Magnesium sulphate versus lytic cocktail for eclampsia[J]. Cochrane Database Syst Rev, 2010, 8(9):CD002960.

共引文献1363

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部