93例女性玫瑰痤疮患者化妆品斑贴试验结果分析

Analysis of cosmetic patch test in 93 female patients with rosacea

目的:检测女性玫瑰痤疮患者化妆品接触性过敏原情况。方法:对2018年1月—2021年12月在我院皮肤科就诊的93例女性玫瑰痤疮患者进行化妆品变应原斑贴试验。结果:93例患者中有68例(73.12%)呈阳性反应,其中阳性率排前4位的变应原种类分别是金属盐类(41例)、表面活性剂类(37例)、防腐剂类(30例)和芳香剂类(24例),阳性率排前9位的具体变应原成分分别是氯化镍(36例)、氯化钴(23例)、十二烷基硫酸钠(16例)、戊基肉桂醇(14例)、烷基醇聚氧乙烯醚(12例)、硫酸镍(12例)、硫柳汞(11例)、硫酸钠(11例)和橡苔浸膏(10例)。结论:化妆品接触性过敏原可能与玫瑰痤疮的发病和复发有关,金属盐类、表面活性剂类、防腐剂类和芳香剂类是最常见的化妆品变应原种类。

Objective:To detect the contact allergens in female patients with rosacea.Methods:The cosmetic patch test were performed in patients with rosacea visited our clinic from January 2018 to December 2021.Results:Among the 93 patients enrolled,68(73.12%)cases presented a positive reaction,and the top four categories of cosmetic allergens were metalsalts(41 cases),surfactants(37 cases),preservatives(30 cases)and aromatics(24 cases).The top 9 specific allergen ingredients with the highest positivity rate were nickel chloride(36 cases),cobalt chloride(23 cases),sodium dodecyl sulfate(16 cases),amylcinnamyl alcohol(14 cases),alkyl alcohol polyoxyethylene ether(12 cases),nickel sulfate(12 cases),thiomersalate(11 cases),sodium sulfate(11 cases),and oakmoss extract(10 cases).Conclusion:Cosmetic contact allergens may be associated with the onset and recurrence of rosacea,with metal salts,surfactants,preservatives,and aromatics being the most common types of cosmetic allergens.