肝硬化对心血管系统的影响及相关机制研究进展

Advances in Research on the Effects of Liver Cirrhosis on Cardiovascular System and Related Mechanisms

肝硬化全球发病率高,危害严重。诸多研究表明,肝硬化可能引起患者心血管异常,而后者又与病情的严重程度密切相关,并可能对肝硬化患者的预后造成不良影响。因此,对高动力循环、门脉高压性肺动脉高压、心脏收缩和舒张功能障碍、心电生理异常以及肝硬化心肌病等方面的发病机制及研究新进展进行综述。为进一步深入研究肝硬化的防治策略奠定基础。

Cirrhosis has a high global incidence rate and serious harm.Numerous studies have shown that liver cirrhosis may cause cardiovascular abnormalities in patients,which are closely related to the severity of the condition and may have adverse effects on the prognosis of liver cirrhosis patients.Therefore,the pathogenesis and research progress in hyperdynamic circulation,portal hypertension pulmonary hypertension,cardiac systolic and diastolic dysfunction,cardiac electrophysiologic abnormalities,and cirrhotic cardiomyopathy are reviewed.To lay the foundation for further in-depth research on the prevention and treatment strategies of liver cirrhosis.