STAT3/Th17细胞与干燥综合征的研究进展

Research progress in STAT3/Th17 cells and Sjogren syndrome

信号转导和转录激活因子3(signal transducer and activator of transcription 3,STAT3)是一种细胞内信号转导因子,在细胞的生长、分化、凋亡和免疫应答等方面发挥重要作用。辅助性T细胞17(T helper cell 17,Th17)的异常活化与多种自身免疫性疾病的发生和发展密切相关。STAT3通过诱导Th17细胞过度增殖、异常分化并影响淋巴细胞浸润外分泌腺等机制参与干燥综合征(Sjogren syndrome)的疾病进展,因此阻断STAT3信号转导通路是治疗干燥综合征的潜在药物治疗靶点。本文综述了STAT3通过调节Th17细胞参与干燥综合征发病及进展的研究,并聚焦于STAT3信号通路抑制剂的最新研究进展,为该靶点在干燥综合征的治疗药物相关研究提供依据。

Signal transducer and activator of transcription 3(STAT3)is an intracellular signaling factor that plays a critical role in various cellular processes,including the growth,differentiation,apoptosis,and immune response of cells.Aberrant activation of T helper cell 17(Th17)is closely associated with the morbidity and progress of various autoimmune diseases.STAT3 participates in the pathogenesis of Sjögren syndrome by inducing excessive proliferation and abnormal differentiation of Th17 cells and affecting lymphocyte infiltration into exocrine glands.Therefore,targeting the STAT3 signaling pathway represents a potential novel therapeutic approach for the treatment of Sjogren syndrome.This review summarizes the research of STAT3 in the pathogenesis and progression of Sjogren syndrome through regulating Th17 cells,focusing on current inhibitors targeting the STAT3 signaling pathway as potential therapeutic targets for Sjogren syndrome.