循证理念指导下的个性化护理对免疫联合靶向治疗肿瘤患者遵医行为及心理状态的干预效果

Intervention effect of the personalized nursing guided by evidence-based concept on the compliance behavior and psychological state of tumor patients undergoing immune combined with targeted therapy

目的探讨循证理念指导下的个性化护理对免疫联合靶向治疗的肿瘤患者遵医行为和心理状态的影响。方法选取2021年1月—2023年1月医院接受免疫联合靶向治疗的120例肿瘤患者为研究对象,按照组间基本特征具有可比性的原则分为对照组与观察组,每组60例。对照组采用常规护理方式,观察组则采用循证指导下的个性化护理,比较两组患者护理前后生活质量、癌因性疲乏、自我感受负担、心理状态、营养指标、遵医行为及相关不良反应发生情况。结果护理前,两组生活质量评分、癌因性疲乏评分、自我感受负担比较,差异均无统计学意义(P>0.05)。护理后,观察组患者的生活质量评分高于对照组,差异有统计学意义(P<0.05);癌因性疲乏评分、自我感受负担中的情感负担和身体负担均低于对照组,差异有统计学意义(P<0.05),经济负担则与对照组相比差异无统计学意义(P>0.05)。护理前,两组心理状态、营养指标比较差异无统计学意义(P>0.05)。护理后,观察组患者的抑郁自评量表、焦虑自评量表评分低于对照组,差异有统计学意义(P<0.05),血红蛋白、血清白蛋白则高于对照组,差异有统计学意义(P<0.05);观察组遵医行为程度高于对照组,差异有统计学意义(P<0.05);观察组不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论循证理念下的个性化护理能改善免疫联合靶向治疗的肿瘤患者的生活质量、癌因性疲乏、自我感受负担,缓解患者负面情绪与营养状态,进而提高患者遵医行为,并降低不良反应事件发生率。

Objective To explore the effect of personalized nursing guided by evidence-based concept on compliance behavior and psychological state of tumor patients undergoing immune combined with targeted therapy.Methods A total of 120 tumor patients receiving immune-targeted therapy at the hospital from January 2021 to January 2023 were selected.According to the principle of comparability in basic characteristics between groups,they were divided into a control group and an observation group with 60 cases each.The control group implemented routine nursing care,and the observation group implemented personalized nursing guided by evidence-based practice.The differences in quality of life,cancerrelated fatigue,self-perceived burden,psychological state,nutritional indicators,compliance behavior,and occurrence of adverse reactions in the two groups of patients before and after nursing care were compared.Results Before nursing,there was no statistically significant difference in quality of life scores,cancer-related fatigue scores,and self-perceived burden between the two groups of patients(P>0.05).After nursing,the quality of life score of patients in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05),the cancer-related fatigue score,emotional burden and physical burden in self-perceived burden were lower than those of the control group,the differences were statistically significant(P<0.05),and there was no statistically significant difference in economic burden between the observation group and the control group(P>0.05).Before nursing,there was no statistically significant difference in psychological state and nutritional indicators between the two groups of patients(P>0.05).After nursing,the Self-rating Depression Scale and Self-rating Anxiety Scale scores in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05),the hemoglobin and serum albumin were higher than those in the control group,the differences were statistically significant(P<0.05);the compliance behavior in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05);the total incidence of adverse reaction in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion The personalized nursing guided by the evidence-based concept can improve the quality of life,cancer-related fatigue,and self-perceived burden of tumor patients undergoing immune combined with targeted therapy,and alleviate negative emotions and nutritional status of patients,thereby enhancing patients'compliance behavior and reducing the incidence of adverse reaction events.