6月龄以上婴儿骨密度与纯母乳喂养及孕期钙营养的关系

Correlation of bone mineral density of infants over 6 months of age with the exclusive breastfeeding and gestational calcium nutrition guidance

目的 分析保定地区6月龄以上婴儿骨密度与纯母乳喂养及孕期钙营养指导的关系,为临床应用提供依据。方法 选择保定市妇幼保健院2020年1月至2023年1月正常检查的308例的6月龄以上婴儿,测定婴儿的骨密度行超声骨密度;检测受试者血中25(OH)D3水平;采用spearman相关性检验分析婴儿骨密度与纯母乳喂养及孕期钙营养指导相关性,采用logistic回归模型分析影响婴儿骨密度的独立性因素。结果 骨密度正常组血清25(OH)D3水平明显高于骨密度异常组(P<0.05);骨密度正常组婴儿纯母乳喂养率和孕期钙营养指导率明显高于骨密度异常组(P<0.05);婴儿不同骨密度与纯母乳喂养及孕期钙营养指导均呈现明显正相关(P<0.05);血清25(OH)D3水平、纯母乳喂养率和孕期钙营养指导率是影响婴儿骨密度的独立性保护因素(P<0.05);结论 保定地区6月龄以上婴儿骨密度与纯母乳喂养及孕期钙营养指导呈显著性正相关关系,且纯母乳喂养及孕期钙营养指导也是影响6月龄以上婴儿骨密度的独立性保护因素。

Objective To analyze the relationship between bone mineral density(BMD) of infants over 6 months of age and exclusive breastfeeding and calcium nutrition guidance during pregnancy in Baoding area,and to provide evidence for clinical application.Methods A total of 308 infants over 6 months of age were selected from Baoding Maternal and Child Health Hospital from January 2020 to January 2023,and their BMD was measured by ultrasound.The level of 25(OH) D3 in subjects′ blood was detected.spearman correlation test was used to analyze the correlation between infant bone mineral density and exclusive breastfeeding and calcium nutritional guidance during pregnancy,and logistics regression model was used to analyze the independent factors affecting infant bone mineral density.Results The level of serum 25(OH) D3 in normal BMD group was significantly higher than that in abnormal BMD group(P<0.05).The rate of exclusive breastfeeding and the guidance rate of calcium nutrition during pregnancy in normal BMD group were significantly higher than those in abnormal BMD group(P<0.05).There was a significant positive correlation between different bone mineral density and exclusive breastfeeding and calcium nutrition guidance during pregnancy(P<0.05).Serum 25(OH) D3 level,exclusive breastfeeding rate and calcium nutritional guideline rate during pregnancy were independent protective factors for bone mineral density(P<0.05).Conclusion Bone mineral density(BMD) of infants over 6 months of age is positively correlated with exclusive breastfeeding and calcium nutrition guidance during pregnancy,and exclusive breastfeeding and calcium nutrition guidance during pregnancy are independent protective factors affecting BMD of infants over 6 months of age.