高原低压低氧环境下牙周炎与中枢神经系统炎症的相关性

Correlation of periodontitis with central nervous system inflammation in hypobaric hypoxia environments at plateau

近年来,随着在高原和山区活动人群的增多,高海拔暴露变得越来越普遍,许多基础疾病患者受高原低压低氧环境影响,病程进一步加重甚至导致认知障碍的现象频发。牙周炎是一种常见的炎症性疾病,能诱发牙周局部炎症反应,甚至中枢神经系统炎症。在高海拔环境下,机体出现免疫力下降、组织缺氧等反应,这些反应会促进牙周炎的发生发展,甚至有可能增加牙周炎引发中枢神经系统炎症的风险。随着高原医学研究的不断深入,高原低压低氧环境下牙周炎与中枢神经系统炎症之间的关系引发越来越多的关注。本文就牙周炎与中枢神经系统炎症的研究进展进行综述,并对高原低压低氧环境下牙周炎与中枢神经系统炎症之间的相关性进行讨论。

With the increase in human activity in plateau and mountainous areas in recent years,high-altitude exposure has become increasingly common.Many patients with underlying diseases are affected by hypobaric hypoxia in plateau environments,which further aggravates disease processes and even leads to cognitive disorders.Periodontitis is a common inflammatory disease that induces periodontal local inflammatory responses and even causes central nervous system inflammation.At high altitudes,the body suffers from decreased immunity and tissue hypoxia,which can promote the occurrence and development of periodontitis and may even increase the risk of periodontitis-induced central nervous system inflammation.As plateau medical research advances,the relationship between periodontitis and central nervous system inflammation in hypobaric hypoxia environments at plateau is attracting more and more attention.This work reviews the progress of research on periodontitis and central nervous system inflammation and discusses the correlation between periodontitis and central nervous system inflammation when exposed to hypobaric hypoxia in plateau environments.