铁死亡在脓毒症急性肺损伤中的研究进展

Research progress in the role of ferroptosis in sepsis-associated acute lung injury

脓毒症是由于宿主对感染的反应失调而导致的危及生命的器官功能障碍,死亡率极高,其是导致急性肺损伤(acute lung injury, ALI)的主要危险因素,然而脓毒症ALI的病理生理学和发病机制尚不完全清楚,有效药物极为有限。因此,当务之急是挖掘脓毒症ALI的发病机制,并试图发现有效的干预措施,以改善脓毒症ALI患者的预后。近年来,铁死亡被认为与脓毒症ALI的病理生理过程密切相关,抑制相关细胞铁死亡可有效延缓疾病的发生发展。本文对靶向相关细胞铁死亡的治疗策略进行综述,以期为脓毒症ALI铁死亡相关研究提供借鉴并为脓毒症ALI的治疗提供新的视角。

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection with an extremely high mortality rate,and it is the main risk factor for acute lung injury(ALI).However,the pathophysiology and pathogenesis of sepsis-associated ALI are not fully understood,and effective drugs are extremely limited.Therefore,it is urgent that we explore the pathogenesis of sepsis-associated ALI and attempt to discover effective intervention measures to improve the prognosis of sepsis-associated ALI patients.In recent years,ferroptosis has been considered closely related to the pathological and physiological processes of sepsis-associated ALI,and inhibiting related cell ferroptosis can effectively slow down the occurrence and development of the disease.In this paper,therapeutic strategies targeting ferroptosis in related cells are reviewed to provide a reference for future research on ferroptosis in sepsis-associated ALI and provide a new perspective on potential treatments.