室管膜下区放疗在胶质母细胞瘤中的进展和临床意义

Research progress and clinical significance on radiotherapy of subventricular zone for glioblastoma

胶质母细胞瘤(glioblastoma,GBM)是成人最常见、恶性程度最高的脑肿瘤。室管膜下区(subventricular zone,SVZ)作为成人神经干细胞最集中的部位,可能是GBM干细胞的潜在来源。研究表明SVZ在该疾病的发生发展及复发转移中扮演重要角色,且SVZ受累可以作为GBM患者预后不良的标志物之一。因此,SVZ可能成为GBM患者放射治疗的靶点。另外,SVZ放疗可以改善GBM患者的预后,但是近年来始终存在相互矛盾的研究结果。为了探索SVZ的临床价值,了解SVZ与放疗相关的最新研究进展,文章通过综述相关理论基础研究,列举和评估现有临床证据,探讨SVZ放疗的价值。

Glioblastoma(GBM)is the most common and malignant brain tumor in adults.The subventricular zone(SVZ),as the most concentrated site of adult neural stem cells,may be the potential source of glioblastoma stem cells.Studies have shown that SVZ plays an important role in the occurrence,development,recurrence and metastasis of the disease,and SVZ involvement can be used as a adverse prognostic marker in GBM patients.Therefore,SVZ may be a target for radiotherapy in patients with GBM.Moreover,SVZ radiotherapy can improve the prognosis of GBM,but there have been many contradictory research results in recent years.In order to explore the clinical value of SVZ,it is necessary to discuss the latest research progress between SVZ and radiotherapy.This review summarizes the relevant theoretical basis research,lists and evaluates the existing clinical evidence,and explores the value of SVZ radiotherapy.