牙周炎患者牙周支持治疗对血细胞指标影响的回顾性研究

The effect of supportive periodontal therapy on blood cell indicators in patients with periodontitis:a retrospective study

目的探讨牙周炎患者牙周支持治疗对血细胞指标的影响。方法按照纳入及排除标准,选取2014年1月—2022年3月于长沙市口腔医院就诊且被确诊为牙周炎的患者为研究对象。根据是否定期进行牙周支持治疗,分为定期支持治疗组(74例)和不定期支持治疗组(76例),对比两组血细胞指标水平变化。结果定期支持治疗组中性粒细胞计数(N)、白细胞计数(WBC)、血小板计数(PLT)、全身免疫炎症指数(SII)均低于治疗前(P<0.05);平均红细胞血红蛋白浓度(MCHC)、平均红细胞体积(MCV)、平均血小板体积(MPV)均高于治疗前(P<0.05);血红蛋白浓度(HGB)相对稳定(P>0.05)。治疗后不定期支持治疗组SII较治疗前下降,MPV、MCV则增大(P<0.05)。两组患者治疗后WBC、N、PLT、SII、MCV、MCHC和MPV之间差异有统计学意义(P<0.05)。在5年随访期间,定期支持治疗组WBC、N、PLT、SII呈下降趋势;MCHC、MPV、MCV呈增长趋势。结论积极的牙周支持治疗能改善牙周炎患者的血液学参数,缓解体内免疫与炎症失衡状态,有利于治疗效果的维护与提高。

Objective This study aimed to investigate the effect of supportive periodontal therapy(SPT)on blood cell indicators in patients with periodontitis.Methods In accordance with the inclusion and exclusion criteria,patients who were diagnosed with periodontitis at Changsha Stomatological Hospital from January 2014 to March 2022 were included.On the basis of whether SPT was performed on patients or not,patients were divided into maintenance group(74 patients)and nonmaintenance group(76 patients)to compare the differences in blood cell indicators between the two groups.Re⁃sults After treatment,the neutrophil count(N),white blood cell count(WBC),platelet count(PLT),and systemic immune-inflammation index(SII)of the maintenance group decreased(P<0.05);the mean corpuscular hemoglobin concentration(MCHC),mean corpuscular volume(MCV),and mean platelet volume(MPV)increased(P<0.05);the hemoglobin(HGB)showed no significant change(P>0.05).The SII of the nonmaintenance group decreased,whereas the MPV and MCV increased(P<0.05).By comparing the changes in blood cell indicators,we found significant differences in WBC,N,PLT,SII,MCV,MCHC,and MPV between the two groups(P<0.05).During the 5-year follow-up period,a decreasing trend in WBC,N,PLT,and SII and an increasing trend in MCHC,MPV,and MCV in the maintenance group were observed.Conclusion Active SPT could improve the hematological parameters of patients,alleviate the immune and inflammatory imbalance,and benefit the maintenance and improvement of the treatment effect.