微生物-肠-脑轴视域下认知障碍的发病机制及中医药治疗进展

Exploring the pathogenesis of cognitive impairment from the perspective of microbiota-gut-brain axis and advances in traditional Chinese medicine treatment

认知障碍已成为影响老年人群健康的常见疾病,目前仍缺乏行之有效的治疗手段。微生物-肠-脑轴(MGBA)为认识认知障碍提供了新视域,也为今后认知障碍的临床诊疗提供了新方向。文章从MGBA视域出发,探讨了其在认知障碍发病中的作用,同时也归纳了此视域下中医药治疗认知障碍疾病的最新研究进展。结果表明,MGBA可通过免疫炎症途径、神经途径及内分泌途径影响认知障碍的发生发展。同时,相关中药复方、中药单体及针刺治疗手段已被证明能通过调节MGBA改善认知功能,为中医药治疗认知障碍提供了较好的现代阐释。

Cognitive impairment has become a common disorder affecting the health of the elderly population,and there is still a lack of effective treatments.The microbiota-gut-brain axis(MGBA)provides a new perspective for understanding cognitive disorders and a new direction for future clinical diagnosis and treatment of cognitive disorders.Therefore,this paper discusses the role of MGBA in the pathogenesis of cognitive disorders from the perspective of MGBA,and also summarizes the latest research progress in traditional Chinese medicine for the treatment of cognitive disorders in this perspective.The results show that MGBA can affect the development of cognitive disorders through immune,neural and endocrine pathways.At the same time,related herbal compounds,herbal monomers and acupuncture treatments have been shown to improve cognitive function by modulating MGBA,providing a better modern interpretation of TCM for the treatment of cognitive disorders.