MAPK信号通路在鼻咽癌发生发展及治疗中的作用研究进展

Research Progress of Role of MAPK Signaling Pathway in Pathogenesis and Treatment of Nasopharyngeal Carcinoma

鼻咽癌是起源于人鼻咽上皮组织的恶性肿瘤,发生复发和转移的鼻咽癌患者预后不良。促分裂原活化的蛋白激酶(MAPK)信号通路的激活可以通过癌细胞内的机制以及与肿瘤微环境的相互作用调节多种转录活动,从细胞增殖到细胞凋亡、炎症、迁移和血管生成,并促进或抑制肿瘤发生和发展。在鼻咽癌中,MAPK活性异常与鼻咽癌的发生发展机制显著相关,可能是鼻咽癌的潜在治疗靶点。进一步明确MAPK在鼻咽癌中的功能及机制,可为鼻咽癌患者诊断、预后和治疗策略提供参考。

Nasopharyngeal carcinoma is a malignant tumor originating from human nasopharyngeal epithelium.The prognosis of nasopharyngeal carcinoma patients with recurrence and metastasis is poor.Activation of mitogen-activated protein kinase(MAPK)signaling pathways can regulate a variety of transcriptional activities,from cell proliferation to apoptosis,inflammation,migration,and angiogenesis,through mechanisms within cancer cells and interactions with the tumor microenvironment,and promote or inhibit tumorigenesis and development.In nasopharyngeal carcinoma,abnormal MAPK activity is significantly related to the pathogenesis of nasopharyngeal carcinoma,and may be a potential therapeutic target for nasopharyngeal carcinoma.Further research progress on the function and mechanism of MAPK in nasopharyngeal carcinoma can provide reference for the diagnosis,prognosis and treatment strategy of nasopharyngeal carcinoma patients.