他汀类药物在结直肠癌防治中的研究进展

Research progress of statins in the prevention and treatment of colorectal cancer

他汀类药物属于HMG-CoA抑制剂,主要用于降低血脂,预防和治疗心血管疾病。研究表明,他汀类药物在结直肠癌防治中展现出多重作用。它们通过抑制MVA相关途径、抑制炎症反应、增强细胞免疫以及影响肠道微生物等途径,对结直肠癌的发生和发展产生积极防治影响。临床研究发现,他汀类药物还能增强化学、免疫和新辅助治疗的疗效,可作为结直肠癌的预防性和辅助性治疗用药。本文对他汀类药物对结直肠癌的作用机制及防治方面研究的进展进行综述,为探索新型结直肠癌治疗方案提供理论依据。

Statins,known as hydroxymethylglutaryl coenzyme A reductase(HMG⁃CoA)inhibitors,are primarily used to lower blood lipids,preventing and treating cardiovascular diseases.Research indicates that statins exhibit multiple effects in the prevention and treatment of colorectal cancer.They function by inhibiting the MVA pathway,suppressing inflammation,enhancing cellular immunity,and influencing the gut microbiota,positively impacting the onset and progression of colorectal cancer.Clinical studies have additionally uncovered that statin drugs can augment the effectiveness of chemotherapy,immunotherapy,and adjuvant therapies,acting as both pre⁃ventive and adjunctive measures for colorectal cancer.This article critically reviews the research progress on statins in colorectal cancer,aiming to establish a theoretical foundation for exploring innovative treatment options.