CHD5在恶性肿瘤中的研究进展

Roles of CHD5 in malignant tumors

染色质结构域解螺旋酶DNA结合5(CHD5)位于1p36.3,首次被发现于神经母细胞瘤中一个频繁缺失的区域,是染色质重塑家族CHD家族中的第五个成员,通过核小体重塑以及形成去乙酰化复合体从而调节特定基因的转录。CHD5已被确定在多种恶性肿瘤中发挥抑癌基因的作用。有研究表明,CHD5在神经母细胞瘤及其他恶性肿瘤中常通过启动子区超甲基化而表达下调,其表达降低与不良临床表现及预后密切相关。本文主要围绕CHD5在恶性肿瘤中的作用进行综述,旨在为今后的研究提供理论依据。

Chromodomain helicase DNA binding protein 5(CHD5),located on 1p36,was first identified in a region of frequent deletion in neuroblastomas.CHD5 is the fifth member of a family of chromatin remodeling proteins,and it probably functions by forming a nucleosome remodeling and deacetylation complex that regulates the transcription of particular genes.CHD5 has been identified as a tumor suppressor gene(TSG)in many malignant tumors.CHD5 is frequently down-regulated through promoter hypermethylation,and its decreased expression is associated with unfavorable clinical and biological features as well as outcome in neuroblastomas and many other tumor types.This review mainly focuses on the structural characteristics and the role of CHD5 in malignant tumors,aiming to provide a theoretical basis for future clinical research.