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QKI在心血管发育和功能中的研究进展

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摘要 综述QKI(Quaking)在心血管发育和功能中的研究进展。QKI作为核糖核酸结合蛋白(RBP),是核糖核酸(RNA)的信号转导和激活(STAR)基因家族的一个特殊成员,属于异质核糖核蛋白(hnRNP)K同源域(KH)结构域蛋白家族,有QKI-5、QKI-6和QKI-7三种羧基末端结构域不同的选择性剪接异构体。QKI不仅神经系统中发挥作用,在包括心血管发育、骨代谢和癌症进展的领域中也发挥重要作用。
出处 《中西医结合心脑血管病杂志》 2024年第13期2366-2369,共4页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金 国家自然科学基金资助项目(No.82070472)。
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  • 1Wu JL, Reed BB, Grabowski PJ,et al. Function of quaking in myelinatlon: regulation of alternative splicing. Proc Natl Acad Sci USA, 2002,99 : 4233 -4238.
  • 2Li Z, Zhang Y, Li D,et al. Destabilization and mislocalization of myelin basic protein mRNAs in q-mking dysmyelination lacking the QKI RNA-binding proteins. J Neurosci,2000, 20 : 4944 - 4953.
  • 3Zhang Y, Feng Y. Distinct molecular mechanisms lead to diminished myelin basic protein and 2',3' -cyclic nucleotide 3'-phosphodiesterase in qkv dysmyelination. J Neurochem,2001, 77 : 165 - 172.
  • 4Reddy TR, Suhasini M, Xu W, et al. A role for KH domain proteins (Sam68-1ike mammalian proteins and quaking protein) in the post-transcriptional regulation of HIV replication. J Biol Chem, 2002, 277 : 5778 - 5784.
  • 5Liu Z, Luyten I, Bottomley M.I, et al. Structural basis for recognition of the intron branch site RNA by splicing factor 1. Science, 2001, 294 - 1098 - 1102.
  • 6Wu HY, Dawson MR, Reynolds R, et al. Expression of QKI proteins and MAP1B identifies actively myelinating oligodendrocytes in adult rat brain. Mol Cell Neurosci, 2001,17 : 292 - 302.
  • 7Cox RD, Hugill A, Shedlovsky A, et al. Contrasting effects of ENU induced embryonic lethal mutations of the quaking gene. Genomics, 1999,57 : 333 - 341.
  • 8Noveroske JK, Lai L, Gaussin V, et al. Quaking is essential for blood vessel development. Genesis, 2002,32 : 218- 230.
  • 9Pilotte J, Larocque D, Richard S. Nuclear translocation controlled by alternatively spliced isoforms inactivates the QUAKING apoptotic inducer. Genes Dev, 2001,15 : 845- 858.
  • 10Saccomanno L, Loushin C, Jan E, et al. The STAR protein QKI-6 is a translational repressor. Proc Natl Acad Sci USA, 1999,96 : 12605 - 12610.

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