吲达帕胺联合氨氯地平治疗高血压合并冠心病临床研究

Clinical Study of Indapamide Combined with Amlodipine in the Treatment of Hypertension and Coronary Heart Disease

目的探讨吲达帕胺联合氨氯地平治疗高血压合并冠状动脉粥样硬化性心脏病(简称冠心病)的临床疗效。方法选取医院2020年1月1日至2022年12月31日收治的高血压合并冠心病患者90例,采取双盲法均分为对照组和观察组,各45例。对照组患者给予苯磺酸氨氯地平片,观察组患者在对照组基础上加用吲达帕胺,均连续治疗8周。结果治疗后,观察组患者的舒张压(DBP)、收缩压(SBP)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平均显著优于对照组(P<0.05);左室舒张末内径(LVEDd)、左室收缩末内径(LVESd)均显著低于对照组,左室射血分数(LVEF)均显著高于对照组(P<0.05)。观察组治疗总有效率为95.56%,显著高于对照组的82.22%(P<0.05)。观察组和对照组不良反应发生率相当(P>0.05)。结论吲达帕胺联合氨氯地平治疗高血压合并冠心病的临床疗效佳,安全性好,能改善血压、血脂水平和心功能指标。

Objective To investigate the clinical efficacy of indapamide combined with amlodipine in the treatment of hypertension and coronary atherosclerotic heart disease(CHD).Methods Ninety patients with hypertension and CHD admitted to the hospital from January 1,2020 to December 31,2022 were selected and divided into the control group and the observation group by the double-blind method,with 45 cases in each group.The control group was given Amlodipine Besylate Tablets,while the observation group was treated with indapamide based on the control group.Both groups were treated for 8 weeks.Results After treatment,the levels of diastolic blood pressure(DBP),systolic blood pressure(SBP),total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C)in the observation group were significantly higher than those in the control group(P<0.05).The left ventricular end diastolic diameter(LVEDd),and left ventricular end systolic diameter(LVESd)in the observation group were significantly lower than those in the control group,while the left ventricular ejection fraction(LVEF)was significantly higher than that in the control group(P<0.05).The total effective rate in the observation group was 95.56%,which was significantly higher than that the control group 82.22%(P<0.05).The incidence of adverse reactions between the observation group and the control group was comparable(P>0.05).Conclusion Indapamide combined with amlodipine is effective and safe in the treatment of hypertension and coronary heart disease,which can improve blood pressure,lipid levels,and cardiac function indicators.