厄贝沙坦治疗高血压并左心室肥厚临床观察

Clinical Observation of Amlodipine Combined with Irbesartan in the Treatment of Hypertension with Left Ventricular Hypertrophy

目的探讨氨氯地平联合厄贝沙坦治疗高血压并左心室肥厚的临床疗效。方法选取医院2021年1月至2023年12月收治的高血压并左心室肥厚患者120例,根据奇偶数法分为对照组和观察组,各60例。对照组患者予苯磺酸氨氯地平片口服,观察组患者予厄贝沙坦片口服。两组均连续治疗6个月。结果观察组患者治疗后的舒张压、收缩压、舒张末期左心室后壁厚度(LVPWT)、舒张末期室间隔厚度(LVST)、左心室舒张末期内径(LVEDd)均显著降低,左心室射血分数(LVEF)均显著升高。结论氨氯地平联合厄贝沙坦治疗高血压并左心室肥厚,可显著降低患者的血压及LVPWT,LVST,LVEDd,升高LVEF。

Objective To investigate the clinical efficacy of amlodipine combined with Irbesartan Tablets in the treatment of hypertension with left ventricular hypertrophy.Methods A total of 120 patients with hypertension and left ventricular hypertrophy admitted to the hospital from January 2021 to December 2023 were selected and divided into the control group and the observation group based on odd-even number method,with 60 cases in each group.The patients in the control group were given Amlodipine Besylate Tablets orally,while the patients in the observation group were given Irbesartan Tablets orally.Both groups were treated for six months.Results After treatment,the diastolic blood pressure,systolic blood pressure,end-diastolicleft ventricular posterior wall thickness(LVPWT),end-diastolic interventricular septal thickness(LVST),and left ventricular end-diastolic diameter(LVEDd)in the observation group significantly reduced,and left ventricular ejection fraction(LVEF)significantly increased.Conclusion Amlodipine combined with irbesartan can significantly reduce blood pressure,LVPWT,LVST,LVEDd and increase LVEF in patients with hypertension and left ventricular hypertrophy.