便通灵胶囊治疗卒中后便秘患者疗效及对血清L-1β、IL-6、TNF-α和肠道菌群水平的影响

Efficacy of Biantongling Capsule in the treatment of patients with constipation after stroke and its effect on serum IL⁃1β,IL⁃6,TNF⁃αand intestinal flora levels

目的 观察便通灵胶囊治疗脑卒中(CVA)后便秘患者疗效及对血清白细胞介素1β(L-1β)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)和肠道菌群水平的影响。方法 选取2021年5月至2023年5月本院接受治疗的CVA后便秘患者90例,以随机数字表法分为便通灵组、益生菌组、乳果糖组,每组30例。对比三组治疗后总有效率、治疗前后卒中量表(NIHSS)评分、肠道菌群变化、血清炎性因子、胆囊收缩素8(CCK-8)水平以及干预后不良反应发生率。结果 治疗后,便通灵组的治疗总有效率高于益生菌组和乳果糖组,差异有统计学意义(χ^(2)=6.540;P<0.05)。便通灵组治疗后的神经功能NIHSS评分及血清IL-1β、IL-6、TNF-α水平均低于益生菌组和乳果糖组,差异有统计学意义(F=176.026、12.574、17.451、5.143;P<0.05)。治疗后,便通灵组CKK-8水平较益生菌组和乳果糖组更高,差异有统计学意义(F=6.422;P<0.05)。便通灵组治疗后双歧杆菌及乳酸杆菌水平高于乳果糖组,差异有统计学意义(F=25.327、4.716;P<0.05),大肠埃希菌和肠球菌水平低于益生菌组、乳果糖组,差异有统计学意义(F=36.966、28.806;P<0.05)。三组治疗期间不良反应发生率比较差异无统计学意义(χ^(2)=0.310;P>0.05)。结论 相较益生菌和乳果糖,便通灵胶囊治疗CVA后便秘能提高患者疗效,改善神经功能,有效抑制炎症反应,调节肠道菌群,具有较高的安全性。

Objective To observe the curative effect of Biantongling capsule and its influences on levels of serum interleukin 1β(IL-1β),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and intestinal floras in patients with constipation after cerebral vascular accident(CVA).Methods A total of 90 patients with constipation after CVA who were treated at our hospital from May 2021 to May 2023 were selected.They were divided into three groups:Biantongling group,probiotics group and lactulose group using a random num-ber table method,each containing 30 cases.The total effective rate after treatment,NIHSS score before and af-ter treatment,changes in intestinal flora,serum inflammatory factors,CCK-8 levels and incidence of adverse reactions after intervention were compared among the three groups.Results After treatment,the total effective rate of treatment in the Biantongling group was higher than that in the probiotic group and the lactulose group,and the difference was statistically significant(χ^(2)=6.540;P<0.05).After treatment,the NIHSS score of neuro-logical function and the levels of serum IL-1β,IL-6,and TNF-αin the Biantongling group were lower than those in the probiotics group and the lactulose group,and the differences were statistically significant(F=176.026,12.574,17.451,5.143,P<0.05).After treatment,the level of CKK-8 in the Biantongling group was higher than that in the probiotics group and the lactulose group,and the difference was statistically significant(F=6.422,P<0.05).After treatment,the levels of bifidobacteria and lactobacilli in the Bibian Tongling group were higher than those in the lactulose group,and the differences were statistically significant(F=25.327,4.716,P<0.05).The levels of Escherichia coli and Enterococcus were lower than those in the probiotics group and the lactulose group,and the differences were statistically significant(F=36.966,28.806,P<0.05).There was no significant difference in the incidence of adverse reactions among the three groups during treatment(χ^(2)=0.310,P>0.05).Conclusion Compared to probiotics and lactulose,Biantongling capsule can enhance the effi-cacy of patients with constipation after CVA,improve neurological function,effectively inhibit inflammatory response,regulate intestinal flora,and has a high level of safety.