聚集诱导发光材料在疾病诊断中的应用进展

Progress in the application of aggregation⁃induced luminescent materials in disease diagnosis

聚集诱导发光(AIE)是由我国科学家引领开拓且国外科学家竞相跟进的新兴科研领域,开发AIE新材料和拓展AIE材料的新应用是材料科学与检验医学交叉共融的前沿热点。具有AIE效应的新型荧光材料克服了传统荧光材料聚集状态下的荧光猝灭效应的不足,其独特的发光机制和性能优势使其在疾病诊断检测领域具有巨大的应用潜力,并已被较广泛开发应用。本文聚焦聚集诱导发光材料在感染性疾病及肿瘤两大热点方向的应用研究进展进行综述,以期为新一代疾病诊断技术的研发提供参考。

Aggregation-induced emission(AIE)is a new scientific research field pioneered by acade-mician Tang Benzhong in China and followed up by foreign scientists.Developing new AIE materials and expand-ing their applications is a frontier hot spot in the cross-integration of materials science and laboratory medicine.New fluorescent materials with AIE effect overcome the deficiency of fluorescence quenching in the aggregation state of traditional fluorescent materials.Their unique luminous mechanism and performance advantages make them have great application potential in disease diagnosis and detection,and they have been widely developed and applied.This review focuses on the application of aggregation-induced luminescence materials in infectious dis-eases and tumors to provide a reference for the development of a new generation of disease diagnosis technology.