脂质组学在肺癌研究中的应用进展

Progress in the Application of Lipidomics in Lung Cancer Research

近年来,脂质组学逐渐在肺癌研究领域崭露头角,为深入研究肺癌的发病机制和治疗策略提供了新的视野。医学技术的不断进步使得脂质组学在肺癌研究中扮演了越来越关键的角色。这不仅有助于肺癌的早期诊断和病情监测,还能为个体化治疗提供更为精准的生物标志物和药效评价。文章重点讨论质谱技术和生物信息学等脂质组学的核心技术在肺癌研究中的应用,并着重分析基于血清和组织样本的脂质组学研究在寻找肺癌特异性生物标志物和识别不同亚型差异方面的重要性。

In recent years,the application of lipidomics in lung cancer research has received increasing attention,providing new perspectives on understanding the pathogenesis and therapeutic strategies of lung cancer.With technological advances,lipidomics will play a more critical role in lung cancer research and provide more specific biomarkers and pharmacodynamic evaluation tools for early diagnosis,condition monitoring,and personalized treatment of lung cancer.This review discusses the critical roles of core technologies like mass spectrometry and bioinformatics in lung cancer research.It also emphasizes the importance of serum and tissue-based lipidomics analysis in exploring specific biomarkers and differences between subtypes of lung cancer.Novel lipidomics strategies provide new directions for elucidating lung cancer pathogenesis and therapeutic strategy selection.