散结消斑方联合八段锦治疗痰瘀互结型颈动脉易损斑块临床研究

Clinical Study of Sanjie Xiaoban Decoction Combined with Baduanjinin Treating Carotid Artery Vulnerable Plaque of Phlegm-stasis Interjunction Type

目的:评价散结消斑方联合八段锦治疗痰瘀互结型颈动脉易损斑块临床价值。方法:将颈动脉易损斑块(痰瘀互结型)患者80例,随机分为治疗组(40例)及对照组(40例)。对照组患者予以西医规范化的抗血小板聚集及降脂稳定斑块治疗,治疗组在对照组基础治疗上加用散结消斑方联合八段锦。对比经过治疗后两组患者颈动脉斑块IMT的变化、斑块总数总斑块面积、Crouse积分及血清学指标。结果:治疗后两组患者颈动脉斑块IMT的变化、斑块总数总斑块面积、Crouse积分、双侧颈动脉中治疗前后最大斑块厚度及面积、总胆固醇、甘油三脂、低密度脂蛋白胆固醇均较治疗前显著降低(P<0.05),高密度脂蛋白胆固醇水平与上升时间值均较治疗前显著升高(P<0.05)。治疗后治疗组颈动脉斑块IMT的变化、斑块总数总斑块面积及Crouse积分、双侧颈动脉中治疗前后最大斑块厚度及面积、总胆固醇、甘油三脂、低密度脂蛋白胆固醇均与对照组比较明显降低(P<0.05),对比于对照组治疗后水平与上升时间值有了明显的升高,经过对于差异比较,均具有统计学意义(P<0.05)。结论:散结消斑方联合八段锦可有效减少痰瘀互结型患者的易损型斑块数目及面积、稳定颈动脉易损斑块、抑制颈动脉粥样硬化斑块进展,值得临床推广。

Objective:To evaluate the clinical value of Sanjie Xiaoban Recipe combined with Baduanjin in the treat-ment of vulnerable carotid plaques with phlegm and blood stasis.Methods:80 patients with vulnerable carotid plaques(phlegm and blood stasis type)were randomly divided into a treatment group(40 cases)and a control group(40 cases).Patients in the control group received standardized Western medicine anti-platelet aggregation,lipid-lowering,and plaque-stabilizing treatments,while the treatment group received Sanjie Xiaoban Recipe combined with Baduanjin in addition to the basic treatment of the control group.The changes in carotid plaque IMT,total plaque area,Crouse score and serological indicators were compared between the two groups of patients after treatment.Results:Changes in ca-rotid artery plaque IMT,total plaque area,Crouse score,maximum plaque thickness and area in both carotid arteries before and after treatment,total cholesterol,triglycerides,and low-density lipoprotein in the two groups of patients after treatment Protein cholesterol was significantly lower than before treatment(P<0.05),and high-density lipoprotein cho-lesterol levels and rising time values were significantly higher than before treatment(P<0.05).Changes in carotid artery plaque IMT,total plaque area and Crouse score,maximum plaque thickness and area in both carotid arteries before and after treatment,total cholesterol,triglycerides,and low-density lipoprotein cholesterol in the treatment group after treatment Compared with the control group,it was significantly reduced(P<0.05).Compared with the control group,the post-treatment level and rising time values were significantly increased.After comparing the differences,they were both statistically significant(P<0.05).Conclusion:Sanjie Xiaoban Recipe combined with Baduanjin can effectively re-duce the number and area of vulnerable plaques in patients with phlegm and blood stasis,stabilize vulnerable carotid plaques,and inhibit the progression of carotid atherosclerotic plaques,which is worthy of clinical practice.promotion.