胞二磷胆碱联合替格瑞洛治疗急性脑梗死伴昏迷患者的疗效观察

Observation on the therapeutic effect of the combination of cytidine diphosphate choline and ticagrelor in the treatment of patients with acute cerebral infarction and coma

目的研究胞二磷胆碱联合替格瑞洛治疗急性脑梗死伴昏迷的预后效果。方法80例急性脑梗死伴昏迷患者,依据随机法分为对照组及观察组,各40例。对照组患者给予替格瑞洛治疗,观察组在对照组基础上联合胞二磷胆碱治疗。比较两组患者治疗效果、不良反应发生情况、昏迷评分、神经功能缺损评分、白细胞介素-6(IL-6)水平、白细胞介素-8(IL-8)水平。结果治疗后,观察组总有效率90.00%高于对照组的70.00%(P<0.05);两组不良反应发生率比较无统计学意义(P>0.05)。治疗后,两组患者的昏迷评分高于治疗前、神经功能缺损程度评分以及IL-6、IL-8水平均低于治疗前,观察组患者的昏迷评分(14.80±1.50)分高于对照组的(12.05±1.30)分,神经功能缺损程度评分(9.60±1.20)分以及IL-6(9.10±0.55)ng/ml、IL-8(2.85±0.20)ng/ml均低于对照组的(13.20±1.50)分、(12.30±1.20)ng/ml、(4.45±0.30)ng/ml(P<0.05)。结论胞二磷胆碱与替格瑞洛联合应用对急性脑梗死伴昏迷患者有确切的临床疗效,能够显著改善患者昏迷状态,修复损伤的神经功能,同时有较高的安全性。

Objective To study the prognostic effect of the combination of cytidine diphosphate choline and ticagrelor in the treatment of patients with acute cerebral infarction and coma.Methods 80 patients with acute cerebral infarction and coma were selected.According to the random method,the patients were divided into a control group and an observation group,with 40 cases in each group.The control group was treated with ticagrelor,while the observation group was treated with cytidine diphosphate choline on the basis of the control group.The treatment effect,occrrence of adverse reactions,coma score,neurological deficit score,interleukin-6(IL-6)and interleukin-8(IL-8)before and after treatment were compared between the two groups of patients.Results After treatment,the total effective rate of the observation group was 90.00%,which was higher than the control group's 70.00%(P<0.05).There was no statistical significance in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the coma score in both groups was higher than that before treatment,and the neurological deficit score and IL-6 and IL-8 levels were lower than those before treatment;the observation group had higher coma score of(14.80±1.50)points than(12.05±1.30)points in the control group;the observation group had neurological deficit score of(9.60±1.20)points,IL-6 of(9.10±0.55)ng/ml and IL-8 of(2.85±0.20)ng/ml,which were lower than(13.20±1.50)points,(12.30±1.20)ng/ml and(4.45±0.30)ng/ml in the control group(P<0.05).Conclusion The combined use of cytidine diphosphate choline and ticagrelor has definite clinical efficacy in patients with acute cerebral infarction and coma.It can significantly improve the patient's coma state,repair damaged nerve function,and has high safety.