苯磺酸左旋氨氯地平片与苯磺酸氨氯地平片治疗高血压的效果对比

Comparison of the efficacy of levamlodipine besylate tablets and amlodipine besylate tablets in the treatment of hypertension

目的对比高血压患者分别应用苯磺酸左旋氨氯地平片与苯磺酸氨氯地平片治疗的临床疗效。方法90例高血压患者,通过随机数字表法分为对照组(45例)、观察组(45例)。给予对照组患者苯磺酸氨氯地平片治疗,给予观察组患者苯磺酸左旋氨氯地平片治疗。比较两组临床疗效、不良反应发生率及治疗前后动态血压[24 h收缩压(SBP)、舒张压(DBP)]、心率(HR)、血清学指标[同型半胱氨酸(Hcy)、B型尿钠肽(BNP)、白细胞介素-6(IL-6)]。结果观察组临床总有效率95.56%(43/45)高于对照组的88.89%(40/45),但差异无统计学意义(P>0.05)。治疗前及治疗后两组组间24 h SBP、24 h DBP、HR比较差异无统计学意义(P>0.05);观察组与对照组治疗后24 h SBP、24 h DBP分别为(144.58±9.06)、(85.26±6.84)mm Hg(1 mm Hg=0.133 kPa)与(146.24±8.58)、(86.47±8.65)mm Hg,均低于治疗前的(164.76±10.47)、(100.95±10.94)mm Hg与(165.87±11.56)、(101.35±11.16)mm Hg(P<0.05);观察组与对照组治疗后HR与治疗前比较差异无统计学意义(P>0.05)。治疗前及治疗后两组组间BNP、Hcy、IL-6水平比较差异无统计学意义(P>0.05);相比治疗前,观察组与对照组治疗后BNP、Hcy、IL-6水平均降低(P<0.05)。治疗后,观察组不良反应发生率2.22%明显低于对照组的17.78%(P<0.05)。结论高血压患者使用苯磺酸左旋氨氯地平片与苯磺酸氨氯地平片治疗,其治疗效果及对血压的控制、血清学指标的影响相近,但苯磺酸左旋氨氯地平片不良反应发生率更低,因此临床可根据患者实际情况进行选择。

Objective To compare the clinical efficacy of levamlodipine besylate tablets and amlodipine besylate tablets in the treatment of hypertension patients.Methods 90 patients with hypertension were divided into a control group(45 cases)and an observation group(45 cases)by random number table method.The control group was treated with amlodipine besylate tablet,and observation group was treated with levamlodipine besylate tablet.Both groups were compared in terms of clinical efficacy,incidence of adverse reactions,ambulatory blood pressure[24 h systolic blood pressure(SBP),diastolic blood pressure(DBP)],heart rate(HR),serological indexes[homocysteine(Hcy),B-type natriuretic peptide(BNP),interleukin-6(IL-6)]before and after treatment.Results The total clinical effective rate of the observation group was 95.56%(43/45),which was higher than 88.89%(40/45)of the control group,but the difference was not statistically significant(P>0.05).There was no significant difference in 24 h SBP,24 h DBP and HR between the two groups before and after treatment(P>0.05).After treatment,24 h SBP and 24 h DBP of the observation group and the control group were(144.58±9.06),(85.26±6.84)mm Hg(1 mm Hg=0.133 kPa)and(146.24±8.58),(86.47±8.65)mm Hg,which were lower than(164.76±10.47),(100.95±10.94)mm Hg and(165.87±11.56),(101.35±11.16)mm Hg before treatment(P<0.05).There was no statistically significant difference of HR in the observation group and the control group after treatment compared with that before treatment(P>0.05).There was no significant difference in BNP,Hcy and IL-6 levels between the two groups before and after treatment(P>0.05).Compared with before treatment,the levels of BNP,Hcy and IL-6 in the observation group and the control group were decreased after treatment(P<0.05).After treatment,the incidence of adverse reactions in the observation group(2.22%)was significantly lower than that in the control group(17.78%)(P<0.05).Conclusion The therapeutic effect and effect on blood pressure control and serological indexes of hypertensive patients treated with levamlodipine besylate tablets and amlodipine besylate tablets are close to each other,but levamlodipine besylate tablets have a lower incidence of adverse reactions,so clinical selection could be made according to the actual situation of patients.