维生素D2注射液联合硫辛酸注射液治疗2型糖尿病合并糖尿病周围神经病变患者的疗效观察

Efficacy observation of vitamin D2 injection combined with lipoic acid injection in the treatment of patients with type 2 diabetes mellitus and diabetic peripheral neuropathy

目的分析2型糖尿病(T2DM)合并糖尿病周围神经病变(DPN)采取维生素D2注射液与硫辛酸注射液联合治疗的效果。方法选择90例T2DM合并DPN患者,依据随机数表分为对照组与研究组,每组45例。对照组以硫辛酸注射液实施治疗,研究组以维生素D2注射液与硫辛酸注射液共同治疗。对比两组患者的临床治疗效果、神经传导速度[正中神经感觉神经传导速度(MSCV)、腓总神经运动神经传导速度(PMCV)、正中神经运动神经传导速度(MMCV)、腓总神经感觉神经传导速度(PSCV)]、血糖指标[糖化血红蛋白(HbA1c)、餐后2 h血糖(2 h PG)、空腹血糖(FPG)]及不良反应发生情况。结果治疗后,研究组总有效率为95.56%,对照组总有效率为82.22%,两组相比研究组更优(P<0.05)。治疗后,研究组MSCV(59.17±3.23)m/s、PMCV(45.89±2.51)m/s、MMCV(46.24±2.24)m/s、PSCV(35.13±2.02)m/s均比对照组的(55.61±2.69)、(43.01±2.27)、(43.29±2.63)、(32.16±3.62)m/s高(P<0.05)。治疗后,研究组HbA1c(6.09±0.78)%、2 h PG(10.83±0.86)mmol/L、FPG(5.35±0.46)mmol/L与对照组的(7.01±0.84)%、(11.82±0.68)mmol/L、(6.96±0.71)mmol/L相比较低(P<0.05)。治疗后,研究组不良反应发生率4.44%与对照组的6.67%相比,差异无统计学意义(P>0.05)。结论T2DM合并DPN采取维生素D2注射液与硫辛酸注射液联合治疗的效果较好,能够使患者的血糖指标得到有效改善,使患者神经传导的速度加快,能有效促进其早日康复,临床上值得推广使用。

Objective To analyze the effect of vitamin D2 injection combined with lipoic acid injection in the treatment of patients with type 2 diabetes mellitus(T2DM)and diabetic peripheral neuropathy(DPN).Methods 90 patients with T2DM and DPN were selected and divided into a control group and a study group according to random number table,with 45 cases in each group.The control group was treated with lipoic acid injection,and the study group was treated with vitamin D2 injection and lipoic acid injection.Patients in both groups were compared in terms of clinical effect,nerve conduction velocity[median sensory nerve conduction velocity(MSCV),peroneal motor nerve conduction velocity(PMCV),median motor nerve conduction velocity(MMCV),peroneal sensory nerve conduction velocity(PSCV)],blood glucose index[glycosylated hemoglobin(HbA1c),2 h postprandial glucose(2 h PG),fasting plasma glucose(FPG)],and the occurrence of adverse reactions.Results After treatment,the total effective rate of the study group was 95.56%,and the total effective rate of the control group was 82.22%;the study group was better than the control group(P<0.05).After treatment,the study group had MSCV of(59.17±3.23)m/s,PMCV of(45.89±2.51)m/s,MMCV of(46.24±2.24)m/s,and PSCV of(35.13±2.02)m/s,which were higher than(55.61±2.69),(43.01±2.27),(43.29±2.63),and(32.16±3.62)m/s in the control group(P<0.05).After treatment,the study group had HbA1c of(6.09±0.78)%,2 h PG of(10.83±0.86)mmol/L and FPG of(5.35±0.46)mmol/L,which were lower than(7.01±0.84)%,(11.82±0.68)mmol/L and(6.96±0.71)mmol/L in the control group(P<0.05).After treatment,the incidence of adverse reactions in the study group was 4.44%,and the difference was not statistically significant from 6.67%in the control group(P>0.05).Conclusion The combination treatment of vitamin D2 injection and lipoic acid injection for T2DM with DPN has a good effect,which can effectively improve the blood glucose index of patients,accelerate the speed of nerve conduction of patients,and effectively promote their early recovery,which is worthy of clinical promotion.