纳米药物递释系统在胃癌治疗中的研究进展

Advances of nanodrug delivery system in gastric cancer treatment

胃癌是最常见的消化道肿瘤之一,发病率居第五位,死亡率居第三位。手术依然是唯一可能治愈胃癌的方法,然而,即便接受根治性切除,绝大多数患者仍然出现肿瘤复发,5年生存率仅为30%。辅助化疗在胃癌术后治疗中起主导作用,化疗虽然可以进一步提高胃癌患者生存,但其副反应发生率高、且需全身多次反复给药。针对传统化疗存在的弊端,开发缓释化疗制剂成为肿瘤治疗领域的热点,其中纳米药物递释系统在缓释化疗方面具有明显的优势。本文对胃癌治疗中纳米药物递释系统的研究进展进行综述。

Gastric cancer is one of the most common digestive tract tumors,with the fifth highest incidence rate and the third highest mortality rate.Surgery remains the only possible cure for gastric cancer,however,even after radical resection,the vast majority of patients still experience tumor recurrence and the 5‑year survival rate is only 30%.Adjuvant chemotherapy plays a leading role in postoperative treatment of gastric cancer.Although chemotherapy can further improve the survival of gastric cancer patients,it has a high incidence of side effects and requires repeated systemic administration.In view of the drawbacks of traditional chemotherapy,the development of extended‑release chemotherapeutic agents has become a hotspot in the field of tumor treatment,among which the nanodrug delivery system has obvious advantages in extended‑release chemotherapy.In this paper,the research progress of nano drug delivery system in gastric cancer treatment is reviewed.