卵巢组织冻存与移植技术新进展

New progresses in ovarian tissue cryopreservation and transplantation

卵巢组织冻存与移植技术不仅保护女性生育力,还可保存卵巢内分泌功能,有效防治医源性早发性卵巢功能不全,尤其适用于青春期前女童与亟需原发病治疗的女性。卵巢组织冻存的有效性与安全性已得到了广泛验证,目前的临床金标准为慢速冻存,而玻璃化冻存仅适用于研究。尽管该技术近年来发展迅速,但仍面临超低温冻存损伤、冷冻保护剂毒性、卵泡储备量的评估、冻存与移植的安全性等问题。本文针对以上问题的研究进展进行综述。

Ovarian tissue cryopreservation and transplantation not only protect female fertility but also preserve ovarian endocrine function.It is effective in the prevention and treatment of iatrogenic premature ovarian insufficiency,especially in prepubertal girls and women in urgent need of disease treatment.The efficacy and safety of ovarian tissue cryopreservation have proved,and the current clinical gold standard is slow freezing,while vitrification is only for research.Despite the rapid development of this technique in recent years,it still faces problems such as cryoinjury,toxicity of cryoprotectants,assessment of follicular reserve,and safety of cryopreservation and transplantation.This article summarizes the progresses of research on these issues.