碘摄入量与甲状腺乳头状癌关系的Meta分析

Meta analysis of the relationship between iodine intake and papillary thyroid carcinoma

目的探究碘摄入量与甲状腺乳头状癌(PTC)的相关性。方法根据PICOS制定检索策略,收集Pubmed、Cochrane Library、Web of Science、CNKI和万方数据库中有关碘摄入量与PTC的病例对照研究共12篇参考文献,共计纳入6214名研究对象,进行Meta分析。结果碘摄入水平过量与PTC的发生有关(OR=5.66,95%CI:2.25~12.68,P<0.001),而适量的碘摄入则能够降低PTC的发生风险(OR=0.26,95%CI:0.13~0.52,P<0.01)。碘摄入水平过量与PTC包膜外侵犯(ENE)、中央区淋巴结转移(CLNM)、BRAF基因突变等无关。结论碘摄入过量增加PTC发生风险,适量的碘摄入是PTC的保护因素。

Objective This study aimed to explore the correlation between iodine intake and papillary thyroid carcinoma(PTC).Methods After formulating a search strategy based on PICOS,12 case-control studies on iodine intake and PTC were collected from PubMed,Cochrane Library,Web of Science,CNKI,and Wanfang databases,including a total of 6214 research subjects,and Meta-analysis was performed.Results The Meta-analysis indicated that there was a positive correlation between excessive iodine intake and the incidence of PTC(OR=5.66,95%CI:2.25~12.68,P<0.05),while moderate iodine intake could reduce the risk of PTC(OR=0.26,95%CI:0.13~0.52,P<0.01).Excessive iodine intake may not be related to such factors as extrathyroidal extension(ENE),the central lymph node metastasis(CLNM),and BRAF gene mutations.Conclusions Excessive iodine intake increases the risk of PTC,and moderate iodine intake may be a protective factor for PTC.