左乙拉西坦与卡马西平对难治性癫痫患者的影响

Impact of Levetiracetam and Carbamazepine on Patients with Refractory Epilepsy

目的观察左乙拉西坦与卡马西平对难治性癫痫患者认知功能、癫痫发作指标及血清指标的影响。方法将2022年9月至2023年9月南阳市中心医院收治的88例难治性癫痫患者作为研究对象,以随机数字表法为依据将其随机划分为参照组(n=44)、研究组(n=44),参照组实施卡马西平治疗法、研究组使用左乙拉西坦治疗法,对两组认知功能、癫痫发作指标、血清神经因子指标及不良反应发生情况进行比较分析。结果治疗后,研究组韦氏成人智力量表(WAIS-RC)语言智商、操作智商、总智商分值均比参照组高,差异有统计学意义(P<0.05);治疗后,研究组癫痫发作频率、分值均比参照组低,差异有统计学意义(P<0.05);治疗后,研究组神经元特异性烯醇化酶(NSE)、中枢神经特异蛋白β(S100β)、髓鞘碱性蛋白(MBP)水平均比参照组低,差异有统计学意义(P<0.05);研究组不良反应发生率比参照组低,差异有统计学意义(P<0.05)。结论左乙拉西坦可有效改善难治性癫痫患者的认知功能,同时可以降低患者的癫痫发作频率与持续时间,并对改善相关血清神经因子表达。

Objective To observe the impact of levetiracetam and carbamazepine on cognitive function,epilepsy attack indicators,and serum indicators in patients with refractory epilepsy.Methods A total of 88 patients with refractory epilepsy treated in Nanyang Central Hospital from September 2022 to September 2023 were selected as the research subjects.They were randomly divided into the reference group(n=44)and the research group(n=44)based on the random number table method.The reference group was treated with carbamazepine,and the research group was treated with levetiracetam.The cognitive function,epilepsy attack indicators,serum neurotrophic factor indicators,and adverse reactions of the two groups were compared and analyzed.Results After treatment,the scores of the Wechsler Adult Intelligence Scale(WAIS-RC)for verbal IQ,performance IQ,and total IQ in the research group were all higher than those in the reference group,with statistically significant differences(P<0.05).After treatment,the frequency and score of epilepsy attacks in the research group were lower than those in the reference group,with statistically significant differences(P<0.05).After treatment,the levels of neuron-specific enolase(NSE),central nervous system-specific proteinβ(S100β),and myelin basic protein(MBP)in the research group were all lower than those in the reference group,with statistically significant differences(P<0.05).The incidence of adverse reactions in the research group was lower than that in the reference group,with a statistically significant difference(P<0.05).Conclusion Levetiracetam can effectively improve the cognitive function of patients with refractory epilepsy,reduce the frequency and duration of epilepsy attacks,and improve the expression of related serum neurotrophic factors.