黏弹性试验在脓毒症中的临床应用进展

Progress of clinical application of viscoelastic testing in sepsis

脓毒症是感染、烧伤、休克等急危重症患者易发生的严重并发症,具有高发病率及高死亡率的特点。如何尽早诊断并快速有效阻止脓毒症的形成与发展是提高急危重症患者救治成功的关键。与常规凝血试验(Conventional coagulation test,CCT)相比,黏弹性试验(Viscoelastic testing,VET)如血栓弹力图(Thromboelastography,TEG)或旋转血栓弹力图(Rotation thromboelastometry,ROTEM)通过在全血样本中进行测试,能够提供更多关于止血的信息,有效监测脓毒症患者的凝血功能,评估脓毒症患者的病情严重程度以及对死亡风险的预测。本文就近年来VET在脓毒症患者中的临床应用进展进行综述。

Sepsis is a serious complication prone occuring in critically ill patients with infection,burns,and shock.It is characterized by high morbidity and mortality.How to diagnose as early as possible and prevent the formation and development of sepsis quickly and effectively is the key to improving the success rate of treatment for emergency and critically ill patients.Compared with conventional coagulation tests,viscoelastic testing(VET),such as thromboelastography(TEG)or rotational thromboelastography(ROTEM),can provide more information about hemostasis by testing in whole blood samples,effectively monitor coagulation function in sepsis patients,evaluate severity of illness and prediction of risk of death in patients with sepsis.This article reviews the progress of clinical application of VET in patients with sepsis in recent years.