钯催化环加成反应构建中环化合物的研究进展

Advances in Palladium-Catalyzed Cycloaddition Reactions for the Construction of Medium-ring Compounds

中环化合物(7—11元环)广泛存在于许多天然产物及药物等功能分子之中,这些分子因具有优异的生物活性及特殊的骨架结构等优点,展现出极其重要的药用价值,如常见的抗癌药物紫杉醇、抗菌药物Spiroxin A等。同时,这类化合物也对化学、医药以及材料等诸多领域产生了深远的影响。但受动力学和热力学因素影响,中环化合物的高效构建依然是一个严峻的挑战。在科研工作者们的不懈努力下,近年来发展出多个新型环加成反应催化体系,其中钯催化环加成反应凭借高效、高选择性和原子经济性等优点在该领域得到了迅猛发展。本文详细介绍了近五年国内外有关钯催化环加成反应构建中环化合物研究的最新进展,旨在为该领域的发展提供一定的帮助。

The medium-ring compounds(7 to 11-membered rings)are widely found in functional molecules,such as many natural products and drugs.These molecules show great medicinal value due to their excellent biological activity and special backbone structure,exemplified by the common anti-cancer drug paclitaxel and the anti-bacterial drug Spiroxin A,and have also exerted a profound impact on many fields including chemistry,medicine and materials.However,the efficient construction of medium-ring compounds has long been a serious challenge,owing to the unfavorable kinetic and thermodynamic factors.Fortunately,thanks to the unremitting efforts of researchers,there have emerged and been proved effective several new catalytic systems for cycloaddition reactions in recent years,among which the palladium-catalyzed cycloaddition reactions have found rapid development in this field by virtue of high efficiency,high selectivity and atomic economy.This article details global research progress in the past five years on the use of palladium-catalyzed cycloaddition reactions to construct medium-ring compounds,expecting to provide helpful information and insight for the research community.