坦度螺酮联合阿米替林对产后抑郁患者的临床疗效

Clinical efficacy of tanospironone and amitriptyline in patients with postpartum depression

目的 分析坦度螺酮联合阿米替林对产后抑郁患者的临床疗效。方法 选取2022年1月至12月温州市第七人民医院收治的产后抑郁患者98例,按治疗方法不同分为对照组49例和研究组49例,对照组给予阿米替林治疗,研究组在对照组的基础上给予坦度螺酮。比较2组汉密尔顿抑郁量表(HAMD)、爱丁堡产后抑郁量表(EPDS)、抑郁自评量表(SDS)、匹兹堡睡眠质量指数(PSQI)评分及5-羟色胺(5-HT)、去甲肾上腺素(NE)、多巴胺(DA)、γ-氨基丁酸(GABA)、卵泡刺激素(FSH)、促黄体生成素(LH)、雌二醇(E_(2))水平;对比2组治疗效果,并统计2组不良反应。结果 治疗后,与对照组相比,研究组HAMD、EPDS、PSQI、SDS评分及FSH、LH水平降低更明显(t=3.011、P=0.003,t=2.966、P=0.004,t=6.145、P<0.01,t=3.595、P=0.001,t=6.001、P<0.01,t=5.377、P<0.01);5-HT、NE、DA、GABA、E2水平升高更明显(t=10.320、P<0.01,t=2.588、P<0.01,t=8.669、P<0.01,t=4.842、P=0.001,t=4.301、P=0.001);研究组总有效率高于对照组(χ^(2)=6.806,P=0.009);2组不良反应发生率比较差异无统计学意义(χ^(2)=1.333,P=0.248)。结论 对产后抑郁患者采取坦度螺酮联合阿米替林治疗,可有效改善患者抑郁程度,提高睡眠质量,治疗效果显著,且安全性较高。

Objective To investigate the clinical efficacy of tandospirone and amitriptyline in postpartum depression patients.Methods A total of 98 postpartum depression patients admitted to Wenzhou Seventh People′s Hospital from January 2022 to December 2022 were divided into a control group and a study group according to treatment,with 49 cases in each group.The control group was treated with amitriptyline,and the study group was given tandospirone on the basis of the control group.The Hamilton Depression Scale(HAMD),Edinburgh Post-partum Depression Scale(EPDS),Self-rating Depression Scale(SDS),Pittsburgh Sleep Quality Index(PSQI),and 5-hydroxytryptamine(5-HT),norepinephrine(NE),dopamine(DA),y-aminobutyric acid(GABA),follicle stimulat-ing hormone(FSH),luteinizing hormone(LH)and estradiol(E_(2))were compared between two groups;The treatment effects of two groups were compared and the adverse reactions between the two groups were caculated.Results After treatment,compared with the control group,the study group showed a more significant decrease in HAMD,EPDS,PSQI,SDS scores,FSH,LH levels(t=3.011,P=0.003;t=2.966,P=0.004;t=6.145,P<0.01;t=3.595,P<0.01;t=6.001,P<0.01;t=5.377,P<0.01;t=8.900,P<0.01).The levels of 5-HT,NE,DA,GABA,and E2 were in-creased more significantly(t=10.320,P<0.01;t=2.588,P=0.001;t=8.669,P<0.01;t=4.842,P=0.001;t=4.301,P=0.001).The total effective rate of the study group was higher than that of the control group(χ^(2)=6.806,P=0.009);There was no statistically significant difference in the incidence of adverse reactions between the two groups(χ^(2)=1.333,P=0.248).Conclusion The treatment of postpartum depression patients with tandospirone combined with amitriptyline can effectively improve the degree of depression and sleep quality,with significant therapeutic effects and high safety.