基于期刊文献数据库的冠心病心律失常中医用药规律研究

Study on the rule of traditional Chinese medicine medication for coronary heart disease and arrhythmia based on journal literature database

目的 运用数据挖掘方法分析中医治疗冠心病心律失常的临床用药规律。方法 收集维普网数据库、万方数据知识服务平台和中国知网(CNKI)等数据库中以冠心病心律失常为主题词收集相关的文献,检索时限自建库至2023年1月,并筛选出中药处方数据,利用Excel 2019归纳整理原始方药数据,核对各味中药的性、味、归经信息并分别进行频数统计。应用SPSS Modeler 18.3软件基于Apriori算法进行关联规则分析,应用IBM SPSS Statistics 25.0对处方数据进行聚类分析和因子分析。结果 共收录符合标准的文献99篇,从中录入中药处方99组,包含133味中药,中药累积使用频次1 091次。其中甘草、丹参、桂枝等高频中药(频次≥20)共16味,性味以温、寒、甘、苦居多,归经主要以脾经、肝经、肺经为主,二阶关联规则分析中以甘草—桂枝支持度最高;三阶关联药物中以甘草—麦冬—丹参的组合支持度最高。因子分析降维得出5个公因子,功效主要有滋阴养血、益气活血等。结论 冠心病心律失常用药性味以苦寒为主,多从脾、肝、肺三经出发,功效相对集中,以滋阴养血、益气通脉为主。

Objective Data mining method was used to analyze the clinical medication rule of traditional Chinese medicine in the treatment of coronary heart disease and arrhythmia.Methods Collected relevant literature with coronary heart disease and arrhythmia as the subject words in VIP database,Wanfang Data knowledge service platform,CNKI and other databases.The retrieval time limit was from the establishment of the database to January 2023,and screened out the prescription data of traditional Chinese medicine.Used Excel 2019 to summarize and sort out the original prescription data,checked the information of nature,flavor and meridian of each traditional Chinese medicine,and made frequency statistics respectively.SPSS modeler 18.3 software was applied to analyze association rules based on apriori algorithm,and IBM SPSS statistics 25.0 was applied to cluster analysis and factor analysis of prescription data.Results A total of 99 literatures meeting the standard were included,from which 99 groups of traditional Chinese medicine prescriptions were input,including 133 traditional Chinese medicines,with a cumulative frequency of 1091 times.There were 16 high-frequency traditional Chinese medicines(frequency≥20),such as Gancao,Danshen,Guizhi,and so on.The nature and flavor were mainly warm,cold,sweet,and bitter.The meridians were mainly spleen meridians,liver meridians,and lung meridians.In the second-order association rule analysis,the support of Gancao-Guizhi was the highest.The combination of Gancao-Maidong-Danshen had the highest support among the third-order related drugs.Factor analysis revealed five common factors with the effects of nourishing yin and blood,supplementing qi and activating blood circulation.Conclusion The medicinal nature and flavor of arrhythmia in coronary heart disease is mainly bitter cold,which mainly starts from the three meridians of spleen,liver and lung.The efficacy is relatively concentrated,and mainly focuses on nourishing yin and blood,supplementing qi and activating pulse.