补肺汤联合沙美特罗替卡松吸入粉雾剂治疗慢性持续期支气管哮喘的临床效果

Clinical efficacy of Bufei decoction combined with salmeterol xinafoate and fluticasone propionate powder for inhalation in the treatment of chronic persistent asthma

目的观察补肺汤联合沙美特罗替卡松吸入粉雾剂治疗慢性持续期支气管哮喘的临床效果。方法选取2018年9月—2020年2月邵阳市中医医院收治的慢性持续期支气管哮喘患者80例,根据随机数字表法分为观察组和对照组各40例。在常规治疗基础上,对照组予沙美特罗替卡松吸入粉雾剂治疗,观察组在对照组基础上联合补肺汤治疗,2组均治疗60 d后比较治疗效果、治疗前后肺功能指标[呼气流量峰值(PEF)、第1秒用力呼气容积(FEV_(1))/用力肺活量(FVC)、FEV_(1)]、中医证候积分、支气管激发试验(BPT)阳性率变化。结果观察组患者治疗总有效率为95.00%,高于对照组的67.50%(χ^(2)=9.928,P=0.002);治疗60 d后,2组PEF、FEV_(1)、FEV_(1)/FVC均较治疗前提高,且观察组PEF、FEV_(1)/FVC高于对照组,观察组FEV_(1)提高程度小于对照组(P均<0.01);2组喘息、咳嗽、咯痰、胸闷、哮鸣音等中医证候评分以及BPT阳性率均较治疗前降低,且观察组低于对照组(P均<0.01)。结论补肺汤联合沙美特罗替卡松吸入粉雾剂治疗慢性持续期支气管哮喘的临床效果较好,对患者肺功能指标、中医证候积分的改善以及降低BPT阳性率都有积极作用。

Objective To observe the clinical effect of Bufei decoction combined with salmeterol xinafoate and fluticasone propionate powder for inhalation in the treatment of chronic persistent bronchial asthma.Methods Eighty patients with chronic persistent bronchial asthma admitted to Shaoyang Hospital of TCM from September 2018 to February 2020 were selected.They were divided into an observation group and a control group using a random number table method,with 40 cases in each group.In addition to conventional treatment,the control group received salmeterol xinafoate and fluticasone propionate powder for inhalation,while the observation group received Bufei decoction in conjunction with the control group regimen.After 60 days of treatment,the differences in treatment effects between two groups were compared,as well as the changes in pulmonary function indicators(PEF,FEV_(1)/FVC,FEV_(1)),traditional Chinese medicine syndrome scores,and the rate of positive bronchial provocation tests(BPT)before and after treatment.Results The total effective rate of treatment in the observation group was 95.00%,which was higher than that in the control group of 67.50%(χ^(2)=9.928,P=0.002).After 60 days of treatment,both groups showed improvements in PEF,FEV_(1),and FEV_(1)/FVC compared to before treatment,with the observation group exhibiting higher PEF and FEV_(1)/FVC values than the control group,while the improvement in FEV_(1) was less pronounced in the observation group than in the control group(P<0.01).The TCM syndrome scores(including wheezing,cough,sputum,chest tightness,and wheezing sound)and the BPT positive rates in both groups decreased compared to before treatment,with the observation group being lower than the control group(P<0.01).Conclusion The combination of Bufei decoction with salmeterol xinafoate and fluticasone propionate powder for inhalation shows better clinical efficacy in treating chronic persistent asthma,with positive effects on improving patients′pulmonary function indicators and traditional Chinese medicine syndrome scores,as well as BPT positive rates.