弥漫性血管内凝血临床诊断中凝血检验指标的作用

Role of Coagulation Test Indexes in the Clinical Diagnosis of Diffuse Intravascular Coagulation

目的探讨凝血检验指标对弥漫性血管内凝血的诊断作用。方法选取2022年5月—2023年5月泰安八十八医院收治的93例弥漫性血管内凝血患者为观察组,根据患者的病理特征将观察组分为高凝期(n=30)、消耗性低凝期(n=36)、继发性纤溶亢进期(n=27),另选择同期到院体检的58名健康受试者为对照组。对所有受试者实施凝血指标检验,对比凝血检验结果,以受试者操作特征曲线评价单一及联合凝血指标检测的诊断价值。结果观察组与对照组凝血检验指标相比,差异有统计学意义(P<0.05)。高凝期患者国际标准化比值高于其余两组,部分活化凝血原时间、纤维蛋白原含量、凝血酶时间以及凝血酶原时间水平低于其余两组,差异有统计学意义(P均<0.05)。联合检测曲线下面积为1.000,灵敏度为100.00%、特异度为100.00%,诊断价值最高。结论与单一指标相比,联合凝血检验指标对弥漫性血管内凝血的诊断价值更高,对疾病分期诊断具有参考价值。

Objective To explore the diagnostic effect of coagulation test index on diffuse intravascular coagulation.Methods A total of 93 patients with diffuse intravascular coagulation admitted to Tai'an 88th Hospital from May 2022 to May 2023 were selected as the observation group.According to the pathological characteristics of the patients,they were divided into high coagulation stage(n=30),low consumptive coagulation stage(n=36)and secondary hyperfibri-nolysis stage(n=27).Another 58 healthy subjects who went to the hospital for physical examination at the same period were selected as the control group.Blood coagulation index test was performed on all subjects and the results of blood coagulation test were compared.The diagnostic value of single and combined coagulation tests was evaluated by re-ceiver operating characteristic curve.Results The oagulation test index between the observation group and the control group was compared,the difference was statistically significant(P<0.05).The international normalized ratio of patients in the hypercoagulable phase was higher than that of the other two groups,and the levels of partial activated prothrom-bin time,fibrinogen content,thrombin time and prothrombin time were lower than those of the other two groups,and the differences were statistically significant(all P<0.05).The area under curve of the combined detection was 1.000,with sensitivity of 100.00%and specificity of 100.00%,and the diagnostic value was the highest.Conclusion Com-pared with a single index,the combined coagulation test index is more valuable in the diagnosis of diffuse intravascu-lar coagulation and has reference value in the diagnosis of disease stages.