β_(2)-MG、BUN、CysC及SCr在肾功能损伤中的临床应用价值

Clinical Value of β_(2)-MG, BUN, CysC and SCr in Renal Function Injury

目的分析肾功能损伤中各项指标的应用价值。方法回顾性选取巨野县人民医院于2021年12月—2022年12月收治的100例肾功能损伤患者的临床资料作为观察组,选取同时期100名健康体检者的临床资料作为对照组。对两组各项指标及观察组中不同类型肾功能损伤患者的各项指标进行对比。结果观察组β_(2)-微球蛋白(β_(2)-microglobulin,β_(2)-MG)水平为(5.61±0.47)mg/L、尿素氮(Blood Urea Nitrogen,BUN)水平为(12.67±2.50)mmol/L、血清胱抑素C(Cystatin C,Cys-C)水平为(2.29±0.27)mol/L、血清肌酐(Serum Creatinine,SCr)水平为(184.59±7.15)μmol/L,明显高于对照组的(2.29±0.59)mg/L,(5.26±1.32)mmol/L,(0.82±0.35)mol/L(89.67±9.28)μmol/L,差异有统计学意义(t=44.013、26.211、33.255、81.024,P均<0.05)。随着肾功能损伤程度的不断加深,不同类型肾功能损伤患者的β_(2)-MG、BUN、CysC、SCr检测水平明显增加,差异有统计学意义(r=0.564、0.338、0.451、0.875,P均<0.05)。结论肾功能损伤患者的β_(2)-MG、BUN、CysC及SCr水平会出现异常变化,且随着肾功能损伤程度的不断加深,β_(2)-MG、BUN、CysC及SCr水平也相应增加。

Objective To analyze the application value of various indexes in renal function injury.Methods The clini⁃cal data of 100 patients with renal function injury admitted to Juye County People's Hospital from December 2021 to December 2022 were retrospectively selected as the observation group,and the clinical data of 100 healthy people who received physical examination at the same time were selected as the control group.The indexes of the two groups and the indexes of patients with different types of renal function injury in the observation group were com⁃pared.Results The levels of β_(2)-microglobulin(β_(2)-MG),blood urea nitrogen(BUN),serum cystatin C(Cys-C)and se⁃rum creatinine(SCr)in the observation group were(5.61±0.47)mg/L,(12.67±2.50)mmol/L,(2.29±0.27)mol/L and(184.59±7.15)μmol/L,respectively,they were significantly higher than those in the control group(2.29±0.59)mg/L,(5.26±1.32)mmol/L,(0.82±0.35)mol/L(89.67±9.28)μmol/L,and the differences were statistically significant(t=44.013,26.211,33.255,81.024,all P<0.05).With the deepening of the degree of renal function injury,the levels ofβ_(2)-MG,BUN,CysC and SCr in patients with different types of renal function injury were significantly increased,and the differences were statistically significant(r=0.564,0.338,0.451,0.875,all P<0.05).Conclusion The levels ofβ_(2)-MG,BUN,CysC and SCr of patients with renal function injury will change abnormally,and the levels ofβ_(2)-MG,BUN,CysC and SCr will increase correspondingly with the deepening of renal function injury.