泌尿生殖道感染患者支原体培养结果及耐药性分析

Mycoplasma Culture Results and Antimicrobial Resistance Analysis in Patients with Urinary and Genital Tract Infections

【目的】分析本院泌尿生殖道感染患者支原体培养结果及耐药性。【方法】检测本院收治的188例泌尿生殖道感染患者的泌尿生殖道分泌物,分析其支原体感染和相关药敏情况。【结果】188例支原体培养标本中,阳性率为44.68%(84/188),男16例,女68例。其中单独感染解脲支原体(Uu)患者63例(33.51%),单独感染人型支原体(Mh)6例(3.19%),Uu+Mh混合感染15例(7.98%)。女性单独感染Uu阳性率高于男性(P<0.05),男、女单独感染Mh及Uu+Mh混合感染阳性率比较,差异无统计学意义(P>0.05)。84例阳性患者中,以20~30岁占比最高(34.12%),31~40岁(16.87%)其次,<20岁(7.62%)与>50岁(8.52%)者相对较少,男性与女性各年龄感染阳性率比较,差异均无统计学意义(P>0.05)。63例单独感染Uu的标本对美满霉素、强力霉素、克拉霉素和交沙霉素的敏感度较高,对司帕沙星耐药性最高,克林霉素其次;6例单独感染Mh的标本敏感度较高的抗生素为交沙霉素、美满霉素,对罗红霉素、克拉霉素、阿奇霉素、红霉素耐药性最高;15例Uu+Mh混合感染的标本敏感度较高的抗生素为美满霉素、强力霉素,对罗红霉素、红霉素、阿奇霉素耐药性最高。【结论】本院支原体感染以Uu为主,多见于20~30女性,敏感度较高的抗生素为美满霉素、强力霉素和交沙霉素。

【Objective】To understand and analyze the mycoplasma culture results and antimicrobial resistance of patients with urinary and genital tract infections in our hospital.【Methods】The secretions from the urinary and genital tracts of 188 patients who were treated in our hospital were tested the mycoplasma infection and analyze the related drug sensitivity.【Results】Among 188 mycoplasma culture specimens,the positive rate was 44.68%(84/188),with 16 males and 68 females.Of these,63 cases(33.51%)were solely infected with Ureaplasma urealyticum(Uu),6 cases(3.19%)were solely infected with Mycoplasma hominis(Mh),and 15 cases(7.98%)had co-infection with Uu and Mh.The rate of Uu infection alone was higher in females than in males(P<0.05).No significant difference was found in the rate of infection with Mh alone or co-infection with Uu and Mh between males and females(P>0.05).Among the 84 positive cases,the highest proportion was in the age of 20-30 group(34.12%),followed by the age of 31-40 group(16.87%),with fewer cases in the age<20 group(7.62%)and>50 group(8.52%).There was no significant difference in the positive rate of infection across age groups between males and females(P>0.05).Among the 63 cases solely infected with Uu,higher antibiotic sensitivity was observed for minocycline,doxycycline,clarithromycin,and josamycin,with the highest resistance to sparfloxacin,followed by clindamycin.For the 6 cases solely infected with Mh,higher sensitivity was found to josamycin and minocycline,with the highest resistance to roxithromycin,clarithromycin,azithromycin,and erythromycin.For the 15 cases of co-infection with Uu and Mh,higher sensitivity was found to minocycline,doxycycline,with the highest resistance to roxithromycin,erythromycin,and azithromycin.【Conclusion】Mycoplasma infection in our hospital is predominantly by Uu,most commonly seen in women aged 20-30,which is antibiotic sensitive to minocycline,doxycycline,and josamycin.