双向孟德尔随机化分析胃癌和肌肉减少症的遗传因果关系

Bidirectional Mendelian Randomization Analysis of Genetic Causal Relationships between Gastric Cancer and Sarcopenia

【目的】采用两样本双向孟德尔随机化(MR)分析遗传层面上肌肉减少症与胃癌之间的潜在因果关系。【方法】从公开发布的全基因组关联研究(GWAS)统计数据获取显著性的工具变量(IV)进行两样本MR分析,采用Cochran's Q检验等方法进行敏感性分析保证IV符合三大假设,采用逆方差加权(IVW)等方法评估胃癌和肌肉减少症之间的双向因果关系。【结果】正向MR分析结果显示:胃癌与四肢肌肉质量(ALM)(OR=-0.019,P=0.446)、左手握力(OR=-0.008,P=0.059)、右手握力(OR=-0.010,P=0.220)未发现因果关系(P>0.05);反向MR分析中也未发现上述指标的因果关系(P>0.05)。【结论】胃癌与肌肉减少症在遗传层面上无直接因果关系。

【Objective】To analyze the potential causal relationship between sarcopenia and gastric cancer at the genetic level using two sample bidirectional Mendelian randomization(MR).【Methods】Significant instrumental variables(IV)were obtained from publicly available genome-wide association studies(GWAS)statistical data for two sample MR analysis.Sensitivity analysis was performed using methods such as Cochran's Q test to ensure that IV met the three major hypotheses.Methods such as inverse variance weighting(IVW)were used to evaluate the bidirectional causal relationship between gastric cancer and sarcopenia.【Results】The positive MR analysis results showed that no causal relationship was found between gastric cancer and limb muscle mass(ALM)(OR=-0.019,P=0.446),left hand grip strength(OR=-0.008,P=0.059),and right hand grip strength(OR=-0.010,P=0.220)(P>0.05);No causal relationship was found between the above indicators in the reverse MR analysis(P>0.05).【Conclusion】There is no direct causal relationship between gastric cancer and sarcopenia at the genetic level.