基于炎癌转化理论从气津分阶段论治恶性肺结节的研究进展

Staged Treatment of Malignant Pulmonary Nodules from Qi and Body Fluid Based on Inflammation-cancer Transformation

肺结节是局部的微小病灶,患者多无症状或仅有轻微不适。中医学认为肺结节虽长在局部,但是全身气血津液代谢逐步失衡所致,这与“炎癌转化”学说的理念一致。基于炎癌转化理论从气津分阶段论治恶性肺结节,转化前期以化痰祛湿为主,转化中期需加大活血消肿之药的占比,转化后期需酌加攻癌解毒之力,结合患者的体质、证候予以益气、理气、化气之法且各有侧重,以延缓甚至阻断肺结节恶化。

Pulmonary nodules are small local lesions,and the patients are usually asymptomatic or only have mild discomfort.According to the TCM theory,although pulmonary nodules grow locally,they are caused by the gradual disorders of qi,blood,and body fluid metabolism in the whole body,which is consistent with the concept of inflammation-cancer transformation.According to the concept of inflammation-cancer transformation,malignant pulmonary nodules can be treated by stages from qi and body fluid.Specifically,the treatment should aim at resolving phlegm and eliminating dampness at the early stage of transformation,activating blood and alleviating edema at the middle stage of transformation,and removing cancer toxin at the late stage of transformation.The treatment methods of replenishing qi,regulating qi,and transforming qi should be selected with consideration to the patient′s physical constitution and syndrome to delay or even block the deterioration of pulmonary nodules.