葶黄清肺汤联合平喘咳外敷散治疗喘息性支气管炎疗效研究

Curative effect study on Tinghuang Qingfei decoction combined with Pingchuanke external application powder in treatment of asthmatic bronchitis

目的:探究葶黄清肺汤联合平喘咳外敷散在喘息性支气管炎患儿中的应用价值。方法:择取82例喘息性支气管炎患儿,按照随机数字表法分为联合组(n=41)、对照组(n=41),联合组采用葶黄清肺汤联合平喘咳外敷散治疗,对照组开展平喘咳外敷散治疗。观察两组喘息性支气管炎患儿临床治疗效果,症状消退时间,肺功能[潮气量(TV)、呼气峰流速(PEF)和第1秒用力呼气容积(FEV1)],促炎因子水平[白介素-6(IL-6)、降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)]和不良反应发生情况。结果:用药后联合组临床疗效较对照组高,症状消退所耗时间较对照组短(P<0.05)。用药后,联合组患儿TV、PEF和FEV1分别为(7.69±1.17)ml/kg、(2.81±0.42)L/s和(1.95±0.42)L,较对照组的(6.64±1.92)ml/kg、(2.34±0.45)L/s和(1.67±0.45)L高,差异有统计学意义(均P<0.05)。联合组患儿用药后IL-6、PCT和TNF-α分别为(14.27±3.27)ng/L、(0.67±0.13)ng/ml和(11.81±2.97)ng/L,均低于对照组的(19.69±3.52)ng/L、(1.47±0.22)ng/ml和(15.06±4.29)ng/L,差异有统计学意义(均P<0.05)。两组喘息性支气管炎患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论:葶黄清肺汤联合平喘咳外敷散能有效缩短喘息性支气管炎患儿预后症状消失时间,改善肺功能和炎性症状。

Objective:To explore application value of Tinghuang Qingfei decoction combined with Pingchuanke external application powder in children with asthmatic bronchitis.Methods:82 children with asthmatic bronchitis were selected and classified into combined group(n=41)and control group(n=41)according to random number table method.The combined group were treated with Tinghuang Qingfei decoction combined with Pingchuanke external application powder therapy,while the control group carried out Pingchuanke external application powder therapy.The clinical treatment effect,symptom regression time,lung function[tidal volume(TV),peak expiratory flow(PEF)and forced expiratory volume in the first second(FEV1)],pro-inflammatory factors[interleukin-6(IL-6),procalcitonin(PCT),tumor necrosis factor-α(TNF-α)]and occurrence of adverse reactions were observed in the two groups.Results:After treatment,clinical efficacy in the combined group were higher,and the time of symptom regression shorter than that in the control group(P<0.05).After treatment,TV,PEF and FEV1 in the combined group with(7.69±1.17)ml/kg,(2.81±0.42)L/s and(1.95±0.42)L,which were higher than(6.64±1.92)ml/kg,(2.34±0.45)L/s and(1.67±0.45)L in the control group,difference statistically significant(all P<0.05).The levels of IL-6,PCT and TNF-αin the combined group after medication were(14.27±3.27)ng/L,(0.67±0.13)ng/ml and(11.81±2.97)ng/L,which were lower than(19.69±3.52)ng/L,(1.47±0.22)ng/ml and(15.06±4.29)ng/L in the control group,difference statistically significant(all P<0.05).There were no statistical differences in the incidence rates of adverse reactions between groups of children with asthmatic bronchitis,difference not statistically significant(P>0.05).Conclusion:Tinghuang Qingfei decoction combined with Pingchuanke external application powder can effectively shorten prognosis symptom disappearance time and improve lung function and inflammatory symptoms in children with asthmatic bronchitis.