补阳还五汤有效组分抗缺血性脑卒中研究进展

Research progress on anti-ischemic stroke of effective components of Buyang Huanwu decoction

缺血性脑卒中(IS)在中医学属于“中风”范畴,是目前全球发病率最高的急危重症之一,脑缺血再灌注损伤可造成脑功能受损,也是IS重要病理生理过程。近来研究发现,补阳还五汤可有效治疗IS,减轻缺血再灌注对脑组织的损伤。补阳还五汤中的有效成分与抗血小板凝集、减轻细胞凋亡、抗氧化应激与兴奋性毒性、调节自噬与减轻炎症反应、促进神经干细胞增殖与分化有关。现对补阳还五汤有效组分在抗IS中发挥的作用进行综述,为深入开展研究和临床开发应用提供参考。

Ischemic stroke(IS)belongs to category of“Zhongfeng”in traditional Chinese medicine,and it is one of the acute and critical diseases with the highest incidence in the world at present.Cerebral ischemia-reperfusion injury is an important pathophysiological process of the disease.The results showed that active components of the prescription were related to anti-platelet aggregation,anti-apoptosis,anti-oxidative stress and excitotoxicity,regulation of autophagy and inflammation,promotion of proliferation and differentiation of neural stem cells.The effect of Buyang Huanwu decoction on anti-IS reviewed,in order to provide reference for further research and clinical application.