果糖在肝胰岛素抵抗发生机制中的作用

The role of fructose in the pathogenesis of hepatic insulin resistance

随着经济发展,糖尿病已成为全球最常见的慢性病之一,其中肝胰岛素抵抗是2型糖尿病发生发展的重要原因之一。笔者从果糖通过肝脂质从头合成增加、肝细胞脂肪酸氧化减弱、肝细胞氧化应激激活以及肝炎症反应增强等途径,致使胰岛素通路障碍,以及果糖对胰岛素通路的直接作用等机制作一综述,为肥胖、2型糖尿病等与肝胰岛素抵抗密切相关的疾病防治提供新的思路和方法。

With economic development,diabetes has become one of the most common chronic diseases globally,and liver insulin resistance is one of the key factors for the occurrence and development of type 2 diabetes mellitus.This paper reviews the studies on the direct effects of fructose on insulin pathway and the indirect blocking of insulin pathway through increasing de novo synthesis of liver lipids,weakening fatty acid oxidation in hepatocytes,activating oxidative stress in hepatocytes,and enhancing hepatic inflammatory responses.It provides a new perspective for the diagnosis and treatment of obesity,type 2 diabetes and other diseases closely related to hepatic insulin resistance.