螺[4.4]-壬烷-1,6-二酮的合成及应用研究进展

Advances in the Synthesis and Application of Spiro[4.4]-nonane-1,6-dione

不对称催化反应是获得光学纯化合物最高效的途径之一,而不对称催化反应的动力源于手性配体及催化剂的开发,因此,寻找优势骨架并进行手性配体及催化剂的开发是不对称催化研究的核心内容之一.手性螺环骨架自20世纪90年代被用于不对称合成研究至今已成为一类优势骨架,并广泛应用于手性配体及催化剂的设计与合成.具有螺[4.4]-壬烷骨架的螺[4.4]-壬烷-1,6-二酮是最早应用于手性辅基、配体及催化剂设计合成与应用研究的化合物.对螺[4.4]-壬烷-1,6-二酮的研究历史,从合成到应用进行综述.

Motivated by the development of chiral ligands and catalysts,asymmetric catalytic reactions have been extensively known as one of the most efficient ways to obtain optically pure compounds.Consequently,the exploration of privileged skeletons and the development of corresponding chiral ligands and catalysts have become pivotal objectives in asymmetric catalysis research.Since the 1990s,chiral spiro-scaffolds have played a significant role in the design and synthesis of effective chiral ligands and catalysts.Among these,spiro[4.4]-nonane-1,6-dione stands out as a representative chiral spiro core structure and has been applied in the design,synthesis,and application of chiral auxiliaries,ligands,and catalysts.This paper provides a comprehensive review of the research history regarding the synthesis and applications of spiro[4.4]-nonane-1,6-dione.