老年女性髋部骨折与其RDW及N-MID OC/β-CTX比值的相关性

Correlation between hip fracture and RDW as well as N⁃MID OC/β⁃CTX ratio in elderly women

目的探讨红细胞分布宽度(RDW)、骨钙素N端中分子片段(N-MID OC)与I型胶原羧基末端肽β特殊序列(β-CTX)比值与老年女性髋部骨折风险的相关性。方法以2021年1月至2021年12月,于四川省骨科医院收治的733例年龄大于60岁女性患者为研究对象,其中髋部骨折组375例,未骨折组358例,收集两组患者临床基数资料。采用二元Logistic回归模型分析RDW及N-MID OC/β-CTX比值与老年女性髋部骨折的相关性。结果Logistic回归分析显示年龄、红细胞分布宽度变异系数(RDW-CV)、N-MID OC/β-CTX、钙(Ca)、磷(P)水平为老年女性髋部骨折的风险因素。将RDW-CV、N-MID OC/β-CTX值从小到大排序后等比例分3层,结果显示RDW-CV越高、N-MID OC/β-CTX比值越低,老年女性发生髋部骨折风险越高(P<0.05)。根据受试者工作特征(ROC)曲线,单独与联合检测两指标均可用于骨折的诊断,但联合检测两指标可提高诊断性能,联合检测的曲线下面积(AUC)为0.729,敏感度、特异性分别为60.53%、75.42%。结论RDW-CV及N-MID OC/β-CTX比值与老年女性髋部骨折风险相关。

Objective To explore the correlation between erythrocyte distribution width(RDW),medium molecular fragment of osteocalcin N segment(N⁃MID OC)/special sequenceβcarboxy⁃terminal peptide of collagen I(β⁃CTX)ratio and the risk of hip fracture in elderly women.Methods A total of 731 female patients over 60 years old who were hospitalized in Sichuan Orthopedics Hospital from January 2021 to December 2021 were selected.There were 375 cases with fracture and 358 cases without fracture.The clinical baseline data were collect⁃ed.Binary logistic regression model was used to analyze the correlation between RDW⁃CV,N⁃MID OC/β⁃CTX ratio and hip fracture in elderly women.Results Logistic regression analysis showed that age,RDW⁃CV,N⁃MID OC/β⁃CTX,calcium(Ca)and phosphorus(P)levels were risk factors for hip fracture in elderly women.The values of RDW⁃CV and N⁃MID OC/β⁃CTX were divided into three levels in equal proportion after ordering from small to large,and the results showed that the higher the RDW⁃CV and the lower the N⁃MID OC/β⁃CTX ratio,the higher the risk of hip fracture in elderly women(P<005).According to receiver operating characteristic curve(ROC),both single test and combined test may be used to diagnose fracture,but combined test may improve the diagnostic performance,with area under curve(AUC)of 0729,sensitivity and specificity of 6053%and 7542%,respec⁃tively.Conclusions RDW⁃CV and N⁃MID OC/β⁃CTX ratio are associated with hip fracture in elderly women.