诱导抑郁症患者小胶质细胞炎性反应的机制

Mechanism of inducing microglial inflammatory response in patients with depression

小胶质细胞炎性反应是抑郁症患者及相关动物模型中广泛观察到的病理现象,与抑郁症密切相关。抑郁症中诱导小胶质细胞炎性反应的机制包括下丘脑-垂体-肾上腺(HPA)轴激活后糖皮质激素水平变化直接或间接的调控作用、肠道微生物代谢物通过脑肠轴中免疫与神经途径的作用以及损伤相关分子模式(DAMPs)对小胶质细胞的直接激活作用等。

Microglial inflammatory response is a pathological process frequently found in patients with depression and in animal models,which is believed to be closely related to depression.The potential mechanisms of inducing microglial inflammatory response by depression includes the direct or indirect regulation of glucocorticoid level changes after activation of the hypothalamic⁃pituitary⁃adrenal(HPA)axis,the effect of intestinal microbial metabo⁃lites through immune and neural pathways in the brain⁃gut axis,and the direct activation of damage associated mo⁃lecular patterns(DAMPs)in microglia.