新生儿高氧相关肺疾病的代谢异常

Metabolic abnormalities in hyperoxia⁃induced lung diseases of neonates

高氧会损害新生儿的多个器官和系统,如肺、大脑、肠道等。代谢异常是新生儿高氧相关肺疾病发病过程中重要的早期事件。本文综述了高氧相关新生儿支气管肺发育不良后的糖代谢、脂质代谢增加,氨基酸代谢失调。其潜在机制可能为:高氧会增加线粒体活性氧的形成,高氧也会改变新生儿支气管肺发育不良线粒体动力学,使线粒体融合减少,裂变和自噬增强。迄今的研究也发现许多与代谢相关的酶和代谢物在高氧相关疾病中发生改变。然而,相关内容尚未进行临床研究。未来的研究应侧重于将代谢谱与多组学数据结合,包括转录组测序、基因组学和蛋白质组学等应用于临床研究,以确定高氧相关新生儿肺损伤可能的生物标志物和治疗靶点。为新生儿高氧相关肺疾病代谢异常的治疗提供新策略。

High oxygen(hyperoxia)concentration may damage multiple organs and systems in newborns,such as the lung,brain and intestines.Metabolic abnormalities are important early events in the pathogenesis of neonatal hyperoxia related pulmonary diseases.This article reviews the increased glucose and lipid metabolism as well as dys⁃regulation of amino acid metabolism after hyperoxia related bronchopulmonary dysplasia in newborns.The potential mechanism may be that the high oxygen concentration increases formation of mitochondrial reactive oxygen species(mtROS),and also change the mitochondrial dynamics of neonatal bronchopulmonary dysplasia,leading to reduc⁃tion of mitochondrial fusion,enhances fission and autophagy.This study also finds that many metabolism⁃related en⁃zymes and metabolites are changed during hyperoxia related diseases.However,clinical research has not yet been conducted.Future research should focus on combining metabolic profiles with multi omics data,including transcrip⁃tome sequencing,genomics and proteomics to identify potential biomarkers and therapeutic targets for hyperoxia related neonatal lung injury in order to develop new strategies for the treatment of metabolic abnormalities resulted from neonatal hyperoxia related pulmonary diseases.