AP-1对羊毛KRTs的调控研究

Regulation of Wool KRTs by AP-1

滩羊是我国优良的地方绵羊品种,其裘皮形成的机理极为复杂,且是出生后35 d左右特有的性状。综述转录因子AP-1的组成、功能结构、作用机理和结合特点,以及角蛋白的分类及表达特点,并对AP-1对羊毛KRTs基因特异性启动子的结合位点进行预测,为转录因子对羊毛角蛋白基因的调控研究提供有效的参考。

Tan sheep is an excellent local breed in China,known for its high-quality pelts and distinctive wool characteristics that emerge around 35 days after birth.This study reviews the composition,functional structure,mechanism of action,and binding characteristics of the transcription factor AP-1,along with the classification and expression characteristics of keratin.Additionally,it predicts the binding sites of AP-1 on the specific promoters of wool KRTs genes,providing valuable insights into the regulatory role of transcription factors in wool keratin gene expression.