中国肾脏移植供者来源性感染临床诊疗指南(2023版)

Clinical guidelines for preventing and treating donor-derived infections in kidney transplant recipients in China(2023 edition)

肾脏移植是治疗终末期肾病的有效手段之一,但是肾源短缺是制约肾脏移植发展的瓶颈。自启动器官捐献工作以来,我国器官捐献例数逐年增加,遗体器官捐献已成为肾脏移植供肾的主要来源。器官捐献工作的快速推进在拯救大量器官功能衰竭患者生命的同时,也带来重大挑战,即供者来源性感染(donor-derived infection,DDI)。为了进一步规范肾脏移植DDI的诊断和治疗,中华医学会器官移植学分会组织相关学科专家,从DDI的定义和危险分层、评估和诊断以及DDI的预防和控制等方面共同拟定了本指南,旨在指导我国肾脏移植DDI管理的全流程优化,进一步完善肾脏移植DDI的防控策略,以保障肾脏移植的安全开展。

Kidney transplantation(KT)is the most effective treatment for end stage renal disease(ESRD).However,an acute shortage of donor organs has greatly restricted the development of KT.Since an initiation of organ donation programs,the domestic number of organ donations has been increasing annually,making it a major source for KT.While saving the lives of many patients with organ failure,a rapid development of organ donation also presents significant challenges,particularly in the form of donor-derived infection(DDI).For further standardizing the diagnosis and treatment of DDI in KT,experts of various disciplines were convened by Branch of Organ Transplantation,Chinese Medical Association.Collaboratively formulated,this guideline focused upon the definitions and risk stratifications of DDI,evaluations and diagnoses of DDI,as well as prevention and control measures for DDI.The overall objective was to guide the comprehensive optimal management of DDI in KT in China,further enhancing the prevention and control strategies for DDI and ensuring the safe procedures of KT.