不可切除食管鳞癌转化手术的研究进展及前景

Advances and prospects of conversion surgery for unresectable esophageal squamous cell carcinoma

食管鳞状细胞癌(鳞癌)由于缺乏浆膜,很容易穿透食管壁侵犯邻近器官。cT4b期肿瘤累及主动脉、椎体、气管或支气管邻近器官被认为不可切除。对于不可切除的食管鳞癌,推荐行根治性放化疗或化疗,然而,治疗效果欠佳。随着转化手术的提出,对于最初因邻近器官浸润或远处转移而无法切除的食管肿瘤患者经诱导治疗后可行手术切除。本文就近年来关于不可切除食管鳞癌的转化手术研究作一综述,旨在探讨转化手术的临床应用前景。

Esophageal squamous cell carcinoma can easily penetrate into the esophageal wall and invade adjacent organs due to the lack of serosa.Stage cT4b tumors involving organs adjacent to the aorta,vertebral body,trachea,or bronchus were considered unresectable.For unresectable esophageal squamous cell carcinoma,radical chemoradiotherapy or chemotherapy is recommended.However,the therapeutic effect is poor.With the advent of conversion surgery,surgical resection is feasible after induction therapy for patients with esophageal tumors that are initially unresectable due to adjacent organ invasion or distant metastasis.This article reviews the research on conversion surgery for unresectable esophageal squamous cell carcinoma in recent years in order to explore the clinical application prospects of conversion surgery.